Af-Acetyl-D-galactosamine

D-Glucuronate Af-Acetyl-D-galactosamine Sulfation at C4 or C6 Cartilage and the intervertebral disc... 

Chondroitin 4-sulphate Af-Acetyl-D-galactosamine (1 3 linkage, 4-SO4) D-Glucuronic acid (1 4 linkage)... 

Using optimized conditions (pentanedione 2 equiv., NaHCOs 4 equiv., H2O-THF 2 1, 90°C, 24 h), Ai-acetyl-o-glucosamine (66) gave the gluco- and manno ketones 69a and 70a in a 4 6 ratio and 83% yield, whereas Af-acetyl-o-mannosa-mine (67) led to the same products in a 3 1 ratio and 40% yield. This poor yield has been explained by the instability of 70a in the reaction mixture. These compounds were easily separated by crystallization of their acetylated derivatives 69b and 70b. Applied to A-acetyl-D-galactosamine (68), the same reaction conditions gave the C-glycosidic ketone 71a, isolated as the acetylated compound 71b (Fig. 12, Table 4). 

Af-Acetyl-4-deoi -4-fluoFO-D-galactosamine, synthesis, 198,20(y,201 yV-Acetyl-3,4-di-0-acetyl-6-deoj -6-fluoro-D-galactosamine synthesis, 194,195/... 

H.H. Wandall, H. Hassan, E. Mirgorodskaya, A.K. Kristensen, P. RoepstotfiF, E.P. Bennett, P.A. Nielsen, M.A. Hollingsworth, J. Burchell, J. Taylor-Papadimitriou and H. Clausen, J. Biol Chem., 1997, 272, 23503-23514, Substrate specificities of three members of the human UDP-Af-acetyl-a-D-galactosamine Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-Tl, -T2, and -T3. 

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