Cytotoxicity of activated

The cytotoxicity of activated macrophages depends of the presence of L-arginine biotransformed to L-citrulline and NO2 (Hibbs etal. 1987). N -monomethyl-L-arginine prevented the synthesis of both these products as well as the expression of cytotoxicity. 

Enzymes Degrading Macromolecules. Enzymes that degrade macromolecules such as membrane polysaccharides, stmctural and functional proteins, or nucleic acids, have all shown oncolytic activity. Treatment strategies include the treatment of inoperable tumors with pepsin (1) antitumor activity of carboxypeptidase (44) cytotoxicity of ribonudease (45—47) oncolytic activity of neuraminidase (48—52) therapy with neuraminidase of patients with acute myeloid leukemia (53) antitumor activity of proteases (54) and hyaluronidase treatment in the management of human soHd tumors (55). 

Investigation of cytotoxic antitumor activity of phthalocyanin conjugates with epidermal growth factor 98MI55. 

Since the pioneer work by Merigan in 1967 [1], many kinds of synthetic or natural polyanionic polymers have been examined for their biological activities [2-8], such as cytotoxicity, antiviral activity, antitumor activity, and immunomodulating activity. Although the biological results were interesting, the extent of activity for clinical application was still low. 

Callen DF, Wolf CR, Philpot RM. 1980. Cytochrome P-450-mediated genetic activity and cytotoxicity of seven halogenated aliphatic hydrocarbons in Saccharomyces cerevisiae. Mutat Res 77 55-63. 

NAKAYAMA T, YAMADA M, osAWA T and KAWAKisHi s (1993) Snppression of active oxygen-induced cytotoxicity by flavonoids , Biochem Pharmacol, 45, 265-7. 

Verma RP (2007) Cytotoxicity of Heterocyclic Compounds against Various Cancer Cells A Quantitative Structure-Activity Relationship Study. 9 53-86 Verma RP, see Hansch C (2007) 10 43-74 Viola G, see Gambari R (2007) 9 265-276 Voelter W, see Khan KM (2007) 7 325-346... 

Cytotoxicity of Heterocyclic Compounds against Various Cancer Cells A Quantitative Structure-Activity Relationship Study... 

Alkylation reactions by the iminium methide species are well known in the mitomycin and mitosene literature 4,49,51-53 and are largely responsible for the cytotoxicity/antitumor activity of these compounds. As illustrated in Scheme 7.8, the electron-rich hydroquinone intermediate can also be attacked by the iminium ion resulting in either head-to-head or head-to-tail coupling. The head-to-head coupling illustrated in Scheme 7.8 is followed by a loss of formaldehyde to afford the coupled hydroquinone species that oxidizes to the head-to-head dimer upon aerobic workup. Analogous dimerization processes have been documented in the indole literature, 54-56 while the head-to-tail mechanism is unreported. In order to... 

At cellular level, 6-MP is transformed in a number of active and inactive metabolites, and in the bone marrow, the balance between activation and inactivation of 6-MP is the main determinant of its antiproliferative effect. Similar to other antimetabolites, 6-MP is a prodrug lacking any cytotoxic activity and needs to be activated [3] (Figure 14.1). The first step is 6-MP transformation into 6-thioinosine monophosphate (6-TIMP), which is subsequently converted to 6-thioguanine tri-... 

---