In Vitro Cytotoxicity of the Optically Active P Lactams

These optically active (3-lactams were tested using seven human cancer cell lines against cisplatin and racemic (3-lactam as controls, and the data is shown in Table 2. 

The cell growth inhibition data confirmed that, of the optically active (3-lactam, 66 and 58 were extremely active (obtained from two different pathways), and the activity of the other optical isomer 68 and 59 (obtained from two different pathways) was reduced compared to the racemic (3-lactam 1. 

Tahle 2 In vitro cytotoxicity of optically active [3 lactams on human cancer cell lines (pM) 

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