Sphingomyelin synthesis

Futerman, A.H., Stieger, B., Hubbard, A.L. and Pagano, R. E., 1990, Sphingomyelin synthesis in rat hver occurs predominantly at the ds and medial cistemae of the Golgi apparatus, /. Biol. Chem. 265 8650-8657... 

Despite the fact that cestodes appear to be capable of considerable lipid synthesis, the actual pathways and enzyme systems involved have been little studied. Sphingomyelin synthesis has been investigated in H. diminuta (37), where it probably involves the same five-step pathway thought to occur in vertebrates involving the enzymes serine palmitoyl-transferase,... 

Fig. 4.5. Sphingomyelin synthesis in Hymenolepis diminuta distribution of label in various intermediates, separated by thin-layer chromatography, after incubation with cytidine-5 -diphospho [methyl-13C]choline. The position of the lipid standards is indicated by the arrows, (a) sphingomyelin (b) dihydrosphingosine (c) sphingosine (d) ketosphingosine (e) ceramide. The origin is at band O. d.p.m., disintegrations/min. (After Bankov Barrett, 1985.)...

Bankov, I. Barrett, J. (1985). Sphingomyelin synthesis in Hymenolepis diminuta (Cestoda). Molecular and Biochemical Parasitology, 15 341-7. 

Park TS, Panek RL, Rekhter MD, Mueller SB, Rosebury WS, Robertson A, Hanselman JC, Kindt E, Homan R, Karathanasis SK. Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoEl knockout mice. Atherosclerosis 2006 189 264-272. 

Yasuda S, Kitagawa H, Ueno M, Ishitani H, Fukasawa M, Nishijima M, Kobayashi S, Hanada K. A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis. J. Biol. Chem. 2001 276 43994-44002. Lister MD, Ruan ZS, Bittman R. Interaction of sphingomyelinase with sphingomyelin analogs modified at the C-1 and C-3 positions of the sphingosine backbone. Biochim. Biophys. Acta 1995 1256 25-30. 

Sillence DJ, Allan D (1998) Utilization of phosphatidylcholine and production of diacylglycerol as a consequence of sphingomyelin synthesis. Biochem J 331 251-256... 

Ridgvray ND. 25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells. J Lipid Res 36(1995) 1345-1358. 

Elmendorf, H. G. and Haidar, K. (1993) Identification and localization of ERD2 in the malaria parasite Plasmodium falciparum separation from sites of sphingomyelin synthesis and implications for organization of the Golgi. EMBO J. 12 AKri-AllTi. 

This enzyme catalyses sphingomyelin synthesis from cytidine diphosphate choline. The sphingomyelins ate an important class of structural phospholipids found in cell membrane structures. 

This asymmetric Mannich-type reaction was successfully applied to the synthesis of (1 J ,31 )-N-(3-hydroxy-l-hydroxymethyl-3-phenylpropyl) dodecanamide (HPA-12), which is the first compound that specifically inhibits sphingomyelin synthesis in mammalian cells, and is also expected to act as a drug that inhibits intracellular trafficking of sphingolipids (Scheme 3.27). ... 

This methodology was later used as the key step for the 12-step synthesis of HPA-12, a sphingomyelin synthesis inhibitor in mammalian cells. ... 

Ledesma, M. D. Brugger, B. Bunning, C. Wieland, F. T. Dotti, C. G. Maturation of the axonal plasma membrane requires upregulation of sphingomyelin synthesis and formation of protein-lipid complexes. EMBO J. 1999, 18, 1761-1771. 

Levade, T. Klar, R. Dagan, A. Cherbu, S. Gatt, S. Fluorescent derivatives of sphingomyelin synthesis, use as substrates for sphingomyelinase and for diagnosis of Niemann-Pick disease in cultured cells. NATO ASI Set, Set A.- Life Sci. 1986,116, 803-807. 

Schweizer, A., Clausen, H., Van Meer, G., and Hauri, H.-R, 1994, Localization of O-glycan initiation, sphingomyelin synthesis, and glucosylceramide synthesis in Vero cells with respect to the endoplasmic reticulum-Golgi intermediate compartment, J. Biol. Chem. 269 4035-4041. 

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