Cyproheptadine

To anticipate briefly, shortening the length of the side chain in the phenothiazines from three to two carbon atoms changes I he activity of the products from neuroleptics to antihistaminic iigents. A rather similar effect is seen in the tricyclic antidepressants. Reaction of ketone, 27, with the Grignard reagent I rom 4-chloro-l-methylpipyridine (35) affords the tertiary alco-liol, 36. Dehydration gives the antihistamine, cyproheptadine (37). ... [Pg.151]

Cycle pent hi azide 1, 368 Cyclophosphamide 3, 161 Cycl opryazate 1, 5 2 Cycloserine 14 Cyclothiazide 358 Cycrimine U 47 Cyheptamide 222 Cypenamine 2, 7 Cyprazepam 7, 402 Cyproheptadine 161... [Pg.266]

Dibenzo[a,dlcyclohepta-1,4-diene-5-one Amitriptylin oxide Dibenzo[a,el cycloheptatrien-5-one Cyproheptadine 5H-Dibenzo (a,d 1 cycloheptene Protriptyline... [Pg.1626]

Azatadine maleate Chlorprothixene Cyproheptadine iphenidol Flupentixol Heptabarbitol Mepivacaine Methadone HCI Methallenestril Methohexital sodium Oxitropium bromide Pipethanate ethobromide Pyrithyidione Ethyl bromoacetate Aceclidine... [Pg.1633]

FIGURE 9.20 Design of multiple ligancl activity, (a) Dual histamine HI receptor and leukotriene receptor antagonist incorporating known antihistaminic properties of cyproheptadine and LTD4. (b) Joint ACE/NEP inhibitor formed from incorporating similarities in substrate structures for both enzymes. From [57],... [Pg.194]

C21H23NO 3967-32-6) see Cyproheptadine l-methylpiperidin-4-ylmagnesium chloride (CfiH 2ClMgN 63463-36-5) see Azatadine Cyproheptadine Ketotifen Loratadine Pizotifen... [Pg.2421]

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