Cyproheptadine adverse effects

In 23 patients who took an overdose of Sleep-Qik (valerian dry extract 75 mg, mean dose 2.5 g, hyoscine hydrobromide 0.25 mg, and cyproheptadine hydrochloride 2 mg) the main problems were central nervous system depression and anticholinergic poisoning (7). There was no evidence of liver damage, subclinical, acute, or delayed. It is unlikely that valerian contributed to the adverse effects in these cases. 

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