Cyproheptadine, metabolism

In addition, other drugs such as alosetron (2), cyproheptadine (12), diazepam (13) or tamoxifen (49) are AT-demethylated by various microorganisms as a major metabolic route. The carboxylic acid resulting from the oxidative cleavage of the piperidine ring of phencyclidine (36), probably proceeding through an... 

Cyprino-purple C2 occurrence, 3, 323 Cyproheptadine as antihistamine, 1, 177 metabolism, 1, 237 Cyproquinate... 

Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, interact with drugs including clarithromycin, warfarin, phenelzine, benzotropine, chlorpromazine, diazepam, and cyproheptadine. Cigarette smokers metabolize SSRIs faster. 

Some horses exhibiting signs of photic headshaking respond favorably to treatment with the antihistamine drug cyproheptadine (Wilkins 1997). In addition to antihistaminic action, cyproheptadine has anticholinergic action and is a 5-hydroxytryptamine (serotonin) antagonist, altering proopiomelanocortin peptide metabolism... 

Desmethylcyproheptadine 10,11-epoxide, a biotransformation product of the antihistaminic and antiserotoninergic drug, cyproheptadine inhibited proinsulin and insulin biosynthesis and insulin release in isolated rat pancreatic islets (Chow et al. 1989). Measurement of (pro)insulin (proinsulin and insulin) synthesis using incorporation of H-leucine showed that desmethylcyproheptadine epoxide, desmethylcyproheptadine and cyproheptadine epoxide were 22,10, and 4 times, respectively, more potent than cyproheptadine in inhibiting hormone synthesis. In man, there was no evidence for metabolic alteration at the tricyclic ethylene bridge (C-10, C-11), whereas dog, cat, and rat all metabolise the drug, at least in part, at this site (Porter et al. 1974). A minor N-oxide conjugate as a metabolite of cyproheptadine has been found in man (Johnson et al. 1962). 

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