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Cyclopiazonic acid

4 Cycloplazonic Acid. — Results pertaining to the incorporation into a-cyclopiazonic acid (79) of tryptophan chirally tritiated at C-3, previously published in a preliminary communication, are now available in a pull paper (c. Vol. 6, [Pg.18]

B-cyclopiazonic acid (80), which was incorporated into (79) without [Pg.18]

FIG. 3. The effect of inhibiting the SR on contraction. (A) Spontaneous Ca transients and force, in human pregnant myometrium, before and during 20 gM cyclopiazonic acid (CPA) application. (B) Superimposed force and Ca2+ records taken from M, under control conditions and in the presence of CPA (dotted trace). (Taken from Kupittayanant et al 2002.)... [Pg.12]

FIG. 2. Mechanism of phenylephrine (PE)-mediated wave-like [Ca2+] oscillations in the rabbit inferior vena cava. (A) PE-mediated [Ca2+]j oscillations are completely inhibited by 10 fiM cyclopiazonic acid (CPA), but the average [Ca2+ ]j remains elevated. (B) PE-mediated [Ca2+]j oscillations are abolished by 75 /iM 2-aminoethoxydiphenyl borate (2-APB). (C) Application of 10 piM nifedipine (Nif) reduced the frequency of PE-mediated [Ca2+]j oscillations while additional application of SKF96365 (SKF) completely abolished the remaining [Ca2+] oscillations. (D) Application of 100 /iM 2,4-dichlorobenzamil (2,4-DCB) completely inhibited nifedipine-resistant PE-induced [Ca2+]j oscillations and lowered the [Ca2+]j to a level that is slightly higher than baseline. Additional application of SKF96365 returned the [Ca2+]j level to baseline. (Experimental traces reproduced with permission from Lee et al 2001.)... [Pg.32]

I/R, inward rectification O/R, outward rectification CPA, cyclopiazonic acid TG, thapsigargin CCh, carbamylcholine CIF, Ca2+ influx factor CAM-ant., calmodulin antagonist W/C, whole-cell recording C/A, cell-attached recording P-W/C, perforated whole-cell recording. [Pg.83]

Wayman CP, McFadzean I, Gibson A, Tucker JF 1996 Two distinct membrane currents activated by cyclopiazonic acid-induced calcium store depletion in single smooth muscle cells of the mouse anococcygeus. Br J Pharmacol 117 566—572... [Pg.90]

Burdyga TV, Wray S 1999b The effect of cyclopiazonic acid on excitation-contraction coupling in guinea-pig ureteric smooth muscle role of the sarcoplasmic reticulum. J Physiol 517 855-865... [Pg.216]

Nomura Y, Asano M, Ito K, Uyama Y, Imaizumi Y, Watanabe M 1997 Potent vasoconstrictor actions of cyclopiazonic acid and thapsigargin on femoral arteries from spontaneously hypertensive rats. Br J Pharmacol 120 65—73... [Pg.253]

Several of the proteins that mediate Ca2+ flow in and out of SR have been identified. Oxalate-facilitated Ca2+ uptake into the SR and in vitro biochemical studies of purified SR identified it as an ATP-driven Ca2+ pump (SERCA pump reviewed in Himpens et al 1995) that is inhibited by thapsigargin and cyclopiazonic acid and regulated, at least in some smooth muscles, by phosphorylation of phospholamban by cyclic nucleotide-activated protein kinase(s) (Karczewski et al 1998). [Pg.259]

Cyclopiazonic acid is synthesized by a number of Aspergillus and Penicillium spp. The Aspergillus spp. that have been reported as cyclopiazonic-acid producers are A. flavus (the most studied cyclopiazonic-acid producer) along with A. versicolor, A. oryzae, and A. tamarii. Among the Penicillium spp. producers are P. verrucosum, P. patulum, P. camembertii, and P. puberulum. In A. flavus, cyclopiazonic-acid production usually occurs in conjunction with aflatoxin production. However, studies of aflatoxin mutants have shown that synthesizing cyclopiazonic acid is independent of the capacity to synthesize aflatoxin (Horn and Dorner, 1999). Little is known about the impact of... [Pg.221]

Cyclopiazonic acid is a potent inhibitor of calcium uptake and acts as a selective inhibitor of the sarco-endoplasmic reticulum Ca2+ATPases (SERCAs) [53], it induces charge alteration in plasma membranes and mitochondria and it can function as an antioxidant [54]. [Pg.119]

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