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Calmodulin antagonists

Lam HY (1984) Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase. Biochem Biophys Res Commun 118 27-32... [Pg.112]

I/R, inward rectification O/R, outward rectification CPA, cyclopiazonic acid TG, thapsigargin CCh, carbamylcholine CIF, Ca2+ influx factor CAM-ant., calmodulin antagonist W/C, whole-cell recording C/A, cell-attached recording P-W/C, perforated whole-cell recording. [Pg.83]

While all of these events are interconnected, the two most critical are neuronal rapid influx of Ca2+ and activation of nNOS, both which trigger all downstream events. Therefore, directly blocking the toxic effects of glutamate /NO, can be achieved through many means, including selective nNOS inhibitors, Ca2+ channel blockers [NMDA, Kainate/AMPA] [ryanodine-sensitive, IP3], calmodulin antagonists, Ca2+... [Pg.367]

Chappell. Inhibition of phytoalexin NT466 biosynthesis in elicitoritreated tobacco cell-suspension cultures by calcium/ calmodulin antagonists. Plant Physiol 1992 100 1369-1376. [Pg.363]

RS-20 <10> (<10> calmodulin antagonist, prevents the Ca /calmodulin-mediated activation [24]) [24]... [Pg.110]

Marine tunicates are a rich source of intriguing structures and interesting biological activities. Eudistomidin A (1) from the Okinawan tunicate Eudistoma glaucus possesses powerful calmodulin antagonistic activity (IC5o 3 x 10 M). Eudistomidins B-D (2-4) show potent cytotoxicity... [Pg.758]

Progress has been made on purifying the components of PSI1, particularly for cyanobacteria and spinach chloroplasts. The presence of Ca2+ in the cell-breaking system results in enhanced activity on reconstitution, and it may well be that one of the proteins found is a calcium-binding protein, as supported by the inhibitory effect of the calmodulin antagonist chlorpromazine on activity.377... [Pg.591]

Schmidt U, Weinbrenner S (1996) What is the Structure of the Calmodulin Antagonist Konbamide from Theonella sp. Synthesis of Two Isomers by Direct Biomimetic Introduction of Bromine in Hydroxytryptophan-Containing Cyclic Peptides. Angew Chem Int Ed Engl 35 1336... [Pg.428]

Selegiline inhibits the activity of monoamine B, enhances the release of dopamine, blocks the uptake of dopamine, is a calmodulin antagonist, and enhances the level of cyclic AMP, which in turn protects dopaminergic neurons. [Pg.164]

Eudistomidin A (167) was isolated from an Okinawan tunicate (Eudis-toma glaucus) and exhibited strong calmodulin-antagonistic activity (133). Compound 167 was the first calmodulin antagonist of marine origin and is about 15 times more potent than W-7, a well-known calmodulin antagonist. Eudistomidins B, C, and D (168-170) were obtained from the same... [Pg.64]

Trifluoperazine (TFP) is an antipsychotic phenothiazine drug which is bound strongly to brain calmodulin and is a potent calmodulin antagonist. TFP is believed to be bound to... [Pg.195]

Shook JE, Burks TF, Wasley JWF, Norman JA (1989) Novel calmodulin antagonist CGS 9343B inhibits secretory diarrhea. J Pharmacol Exp Ther 251 247-252... [Pg.177]

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See also in sourсe #XX -- [ Pg.7 , Pg.263 ]

See also in sourсe #XX -- [ Pg.351 ]

See also in sourсe #XX -- [ Pg.7 , Pg.245 ]



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