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Cyclooxygenase cerebral

The role of CuZnSOD on oxygen radical production in cerebral vessels has been studied. Didion et al. [28] demonstrated that endogenous CuZnSOD diminished superoxide levels in rabbit cerebral blood vessels and affected nitric oxide- and cyclooxygenase-mediated responses in cerebral microcirculation. A subsequent study by the same group [29] showed increased superoxide production and vascular dysfunction in CuZnSOD-deficient mice. Chang et al. [30] suggested that superoxide induced cytokines, which activated microglial... [Pg.909]

Cyclooxygenase and lipoxygenase products accumulate during reperfusion following cerebral ischemia 586... [Pg.575]

Adams J., Collaco-Moraes Y., and De Belleroche J. (1996). Cyclooxygenase-2 induction in cerebral cortex An intracellular response to synaptic excitation. J. Neurochem. 66 6-13. [Pg.154]

Ellis, E.F., Wright, K.F., Wei, E.P. and Kontos, H.A. (1981) Cyclooxygenase products of arachidonic acid metabolism in cat cerebral cortex after experimental concussive brain injury, J. Neurochem. 37, 892-896. [Pg.237]

Yen MH, Lee SH (1987) Effects of cyclooxygenase and lipoxygenase inhibitors on cerebral edema induced by freezing lesions in rats. Eur J Pharmacol 144 369-373... [Pg.168]

Chen P, Hu S, Yao J, Moore SA, Spector AA, Fang X (2005a) Induction of cyclooxygenase-2 by anandamide in cerebral micro vascular endothelium. Microvasc Res 69 28-35 Chen SR, Wess J, Pan HL (2005b) Functional activity of the M2 and M4 receptor subtypes in the spinal cord studied with muscarinic acetylcholine receptor knockout mice. J Pharmacol Exp Ther 313 765-770... [Pg.490]

Cao C, Matsumura K, Ozaki M, Watanabe Y (1999) Lipopolysac-charide injected into the cerebral ventricle evokes fever through induction of cyclooxygenase-2 in brain endothelial cells. J Neurosci 19 716-725. [Pg.523]

Nogawa S, Forster C, Zhang F, Nagayama M, Ross ME, ladecola C. Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia. Proc Natl Acad Sci USA. 1998 95 10966-10971... [Pg.21]

Pig. 33 Pathways associated with ROS- and RNS-mediated ceU death in cerebral ischemia. Phosphohpase A2 (PLA2) nitric oxide synthase (NOS) cyclooxygenase-2 (COX-2) arachidonic add (ARA) lyso-phosphophatidylcholine (lyso-PtdCho) platelet-activating factor (RAF) reactive oxygen species (ROS) reactive nitrogen species (RNS) superoxide (O2) peroxynitrite (ONOO ) transcription factor-a (TNF-a) interleukin-ip (IL-ip) and interleukin-6 (IL-6)... [Pg.71]

Zhao Y, Patzer A, Herdegen T, Gohlke P, Culman J (2006) Activation of cerebral peroxisome proUferator-activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpression after focal cerebral ischemia in rats. EASEB J 20 1162-1175... [Pg.106]

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