Cyclins, resveratrol inhibition

Resveratrol exerts antitumor effects partly by arresting the growth of various cancer cells in culture [Kundu and Surh, 2004]. The inhibition of ornithine decarboxylase (ODC), a biochemical hallmark of tumor promotion, has been shown to account for the antiproliferative and antitumor effects of resveratrol [Schneider et al., 2000 Ulrich et al., 2007]. Aberrant changes in cell-cycle machinery are considered as the biochemical basis of abnormal proliferation of transformed cells. Major cell-cycle regulatory proteins include various cyclins, cyclin-dependent kinases (Cdk), Cdk inhibitors, and check point kinases (Chkl... 

Mechanistic studies [35] showed combination treatments to inhibit cell proliferation via downregulation of cyclin D1 and induce apoptosis via activation of caspases-8 and -9 and downregulation of prosurvival proteins, FLIP and survivin [35]. Several stUhenes, related to resveratrol, have been synthesized and tested for their anticancer effect on HL-60 leukemia cell line, taking particular care of the cell cycle analysis. Figure 8.2 shows synthesis of stilbenes and its effects on cell cyde. A scheme of flow cytometry analysis of cell cycle is presented in Figure 8.3. The most potent compound was found to be (Z)-3,4, 5-trimethoxystilbene(I)... 

---