Cyclic adenine monophosphate

The receptors start a second messenger cascade that is initiated by activation of G-proteins in the cell. These, in turn, interact with membrane-bound adenylyl cyclase, which catalyzes the formation of cyclic adenine monophosphate (cAMP) and opening of cAMP-gated cation channels. Depolarization then brings about an action potential, which travels along the axon of the olfactory sensory neuron. Many of the molecular components of this cascade are olfactoiy specific. 

A) Inhibition of platelet phosphodiesterases (PDEs) [91]. Quercetin and myricetin potentiated the anti-aggregatory action of prostacyclin (PGI2), a potent stimulator of platelet adenylate cyclase synthesised by the vascular endothelium, on ADP-induced platelet aggregation in washed human platelets, and the elevation of platelet cyclic adenosine monophosphate (cAMP) elicited by PGI2 [89,92,93]. These effects are probably due to an inhibition of PDEs. As suggested by Ferrell and co-workers [92], this inhibition arises from the similarity between the pyranone ring of flavonoids and the pyrimidine ring of adenine. 

Niacin production of reduced nicotinamide adenine dinucleotide (phosphate) (NADPH) by ACTH via cyclic adenosine monophosphate (AMP)... 

This finding confirms the proposal that cellobiose released by the action of a low level of constitutive cellulose is the actual inducer for cultures grown on cellulose [120]. Very little is known about the mechanism of repression in T. fusca. Work on T. curvatae suggests that cyclic adenine 5 -monophosphate (AMP) might play a role [124], but this does not seem to be true for T. fusca... 

CAS 61-19-8. C10H14N5O7P. The monophosphoric ester of adenosine, i.e., the nucleotide containing adenine, d-ribose, and phosphoric acid. Adenylic acid is a constituent of many important coenzymes. Cyclic adenosine-3, 5 -monophosphate is designated by biochemists as cAMP. 

Phosphorylation of nucleosides. Direct phosphorylation of unprotected nucleosides generally leads to a mixture of the three possible phosphates. However, treatment of 2, 3 -0-isopropylidene nucleosides with phosphoryl chloride gives. V-phosphorodichloridates in fair yield. The reaction is greatly improved by use of trimethyl phosphate, (CH30)3P0, ortriethyl phosphate, in which the substrates are moderately soluble. After hydrolysis, 5 -nucleotides are obtained in nearly quantitative yield.1 Adenine nucleosides, such as (1), are readily converted into the 3, 5 -cyclic monophosphate, such as (2), by this procedure.2... 

Abbreviations used NAD+ = nicotinamide adenine dinucleotide NADH e reduced nicotinamide adenine dinucleotide NADP = nicotinamide adenine dinudeotide phosphate NAD PH reduced nicotinamide adenine dinucleotide phosphate NMN, NMN+ nicotinamide mononucleotide NMNH2 = reduced nicotinamide mononucleotide a-NAD a-nicotinamide adenine dinucleotide AMP = 5 -adenylic acid 3,5 -AMP adenosine 3, 5 -cycIic phosphate 3 ,5 -UMP = uridine 3, 5 -cyclic phosphate 3, 5 -CMP cytidine 3, 5-cyclic phosphate 3 f5 GMP = guanosine 3 5f-cyclic phosphate 3, 5 TMP thymidine 3, 5 -cyclic phosphate Dibutyryl-3, 5 -AMP = N6,02-dibutyryladenosine 3, 5 -cyclic phosphate 2, 3 -UMP = uridine 2 ,3 -cyclic monophosphate 2, 3 -CMP cytidine 2, 3 -cyclic monophosphate 2, 3 -AMP = adenosine 2, 3 -cyclic monophosphate 2 ,3 -GMP = guanosine 2 3 -cyclic monophosphate 2 -UMP = uridine 2 -phosphate -UMP uridine -phosphate 5 -UMP = uridine 5 phosphate Poly U polyuridylic acid ADP = adenosine 5 -diphosphate FAD = flavin adenine dinucleotide UpA, UpU, ApU and ApA x dinucleoside phosphates of uridine and/or adenine. c See original references for experimental conditions and additional data. 

A4e3 mechanism, 353 Adenine, 431, 1091 Adenosine, 989,1091 Adenosine 3 -5 -cyclic monophosphate (cycUcAMP), 1093 Adenosine diphosphate, 1093 Adenosine 5 -monophosphate, 1092 Adenosine triphosphate, 1093 reaction with methionine, 641 5-Adenosylmethionine, 314, 641 Adipic acid... 

Adenosine 3, 5 monophosphate (cyclic AMP) (R = adenine in (10.79b)) is of considerable importance in biochemistry. Hydrolysis of this compound with Ba(OH)2 gives a mixture of adenosine 3 phosphate and adenosine 5 phosphate. 

Figure 3.1 shows the nucleotides formed from the purine adenine - the adenine nucleotides, adenosine monophosphate (AMP), adenosine diphosphate (ADP) and adenosine triphosphate (ATP) - as well as the nucleotide triphosphates formed from the purine guanine and the pyrimidine uracil (see also section 10.3.2 for a discussion of the role of cyclic AMP in metabolic regulation and hormone action). 

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