Cyano methane

Relation to Methane and Acetic Acid.— The two syntheses of malonic acid which, prove its constitution also show its relation to methane and to acetic acid as indicated above. Di-cyano methane, which is made from di-chlor methane by the action of potassium cyanide, yields malonic acid on hydrolysis and on that account is also known as malonic nitrile. 

Acetonitril Acetonitrile AI3-00327 CCRIS 1628 Cyanomethane Cyanure de methyl EINECS 200-835-2 Ethyl nitrile HSDB 42 Methane, cyano- Methane-carbonitrile Methyl cyanide Methylkyanid NCI-C60822 NSC 7593 RCRA waste number U003 UN1648 USAF EK-488. Solvent for hydrocarbon extraction processes, especially for butadiene intemnediate catalyst for separation of fatty acids from vegetable oils manufacture of synthetic pharmaceuticals. Liquid mp = -43.8° bp = 81.6° d20 =... 

Formula CH3CN MW 41.05 CAS [75-05-8] Structure and functional group H3C—CsN, the first member of the homologous series of aliphatic nitriles, reactive site —C=N, undergoes typical nitrile reactions Synonyms methyl cyanide ethanenitrile ethyl nitrile methanecarbonitrile cyano-methane... 

Jorgensen and coworkers calculated the relative values for cyano-methane and ethane with respect to methanethiol using FEP (Monte Carlo, OPLS force field) and ab initio [6-31+G(d)] methods. The calculated AAG a, AAGg 3 , AAGg " , calculated pK, and experimental pK for... 

Both have a triple bond that consists of a a and two n bonds, and the shapes of the molecules are similar. In cyano methane, the lone pair... 

The imidazoline denvative cibeiuoline (64) is a class I antiarrhythmic agent which has undergone clinical trials in the United States with apparently satisfactory results It is synthesized by diphenylcyclopropananon of acrylonitrile by thermal carbene generation from diphenyldiazo methane (62) to give 1 cyano 2,2 diphenylc>clopropane (63) Reaction of this with ethylenedia mine tosylate completes the synthesis of ciben/oline (64) [221... 

Bazan and co-workers [93] coupled four branches of stilbene chromophores to a central C atom, leading to tetrastilbenylmethane [C(STB)4, 46a] tetrakis (4-ferf-butylstyryIstiIbenyljmethane [C(f-BuSSB)4, 46b], and the higher homolo-gue tetrakis 4-[4 -(4"-terf-butyl-styryl)styryl]stilbenyl methane [C(4R—f-Bu)4, 46c]. For 46b, Tg is 190°C, and for 46c it is as high as 230°C. Tetrakis(4,4 -2,2-diphenyl-vinyl)-l,l -biphenyl]methane [C(DPVBi)4, 47a] and the cyano derivative 47b exhibit the glass transition at 142 and 174°C, respectively. Similar compounds to 46a and 46b have also been synthesized with silicon and adaman-tane as the tetrahedral center. 

Although the hydroxy group is a relatively poor leaving group, its base-catalyzed nucleophilic substitution by the mechanism shown in Scheme 69 accounts not only for the hydrogenolysis of the 3-hydroxymethylindoles, but also for their SN reactions with ethoxide ions, cyanide ions and with piperidine. Nucleophilic substitution on 2-hydroxymethyl-pyrroles is generally precluded by the faster formation of the bis(2-pyrrolyl)methanes, but the synthesis of 2-cyano-2-(2,5-dimethyl-3-pyrroIyl) propanes from 2,5-dimethylpyrrole, propanone and potassium cyanide probably results from an SN reaction of the cyanide ion upon the initially formed 3-pyrrolylcarbinol (81USP4248784). The formation of (294)... 

The ionization constants,331 NMR spectra,174 and mass spectra1227 of representative amino-1,6-naphthyridines have been compared with those of related amino derivatives. Complexes of l,6-naphthyridin-2-amines with tetracyanoquinodi-methane have been studied.416 4-(3-Dimethylamino-l-methylpropylamino)-l,6-naphthyridine showed significant antimalarial activity.236 X-ray analyses of a number of 5-amino-1,6-naphthyridines have been reported in connection with their antibacterial activities for example, ethyl 5-amino-7-benzylseleno-8-cyano-4-(fur-2-yl)-l,2-dimethyl-l,4-dihydro-l,6-naphthyridine-3-carboxylate (10) proved to be a mixture of two symmetric conformers in each crystal 772 the other related compounds appear to be composed of single conformers.558,560 562 759 781 1289... 

Finally there is the method for the preparation of the symmetrical di-(2-quinolyl)- and di-(4-quinolyl)methanes by which Sperber et al.19 prepared di-(2-pyridyl)methane. By heating 2- or 4-halogen derivatives with sodamide and acetonitrile in dry toluene the 9-cyano compound is formed (6),19a and this yields the corresponding di-quinolylmethane upon refluxing with 70% sulfuric acid [Eq. (4)]. 

The reaction of equimolar quantities of 2-bromopyridine, 2-chloroquinoline, NaNH2, and CHSCN gives the symmetrical 9-cyanodi-(2-pyridyl)- and 9-cyanodi-(2-quinolyl)methanes, and not 9-cyano(2-pyridyl)-(2-quinolyl)-methane.20... 

ETHANENITRILE ETHYL NITRILE METHANECARBONITRILE METHANE, CYANO- METHYL CYANIDE METHYLKYANID NCI-050822... 

METHANE BASE see MJNOOO METHANECARBONITRILE see ABE500 METHANECARBOTHIOLIC ACID see TFA500 METHANECARBOXAMIDE see AAIOOO METHANECARBOXYLIC ACID see AAT250 METHANE, CHLOROTRIFLUORO-, mixt. with TRIFLUOROMETHANE (9CI) see F00562 METHANE, CYANO- see ABE500 METHANEDICARBOXYLIC ACID, DIETHYL ESTER see EMA500... 

Introduction of a cyano group a to the carbonyl group of a ketone can be accomplished by prior formation of the enolate anion with LDA in THF and addition of this solution to p-TsCN at —78°C. The products are formed in moderate to high yields but the reaction is not applicable to methyl ketones. Treatment of TMSCH2N(Me)C=Nf-Bu with iec-butylhthium and R2C=0, followed by iodo-methane and NaOMe leads to the nitrile, R2CH-CN. ... 

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