Cyano group detection

To improve the detectability of silyl ethers, silylation reagents containing an electron-capturing group [443,449-451,468] or cyano group for thermionic detection [469] have been prepared, the 2-cyanoethyldimethylsilyl derivatives are only marginally aore sensitive (ca. 5 fold) to the thermionic detector than to the flame ionization det ftpr which Units their usefulness. The... 

Through the use of IR spectroscopy, the equilibria 90A 90B and 91A 91B were detected [90DOK(313)110] under the conditions of basic catalysis [2% (Et)3N in dioxane solution]. Two cyano groups and the C(CN)2 group increase the acidity of the C—H group. In the last equilibrium, two epimers of 91B were detected. 

IgG detection based on the electrostatic binding between the terminal cyano group of a N-substituted PIV bearing CN and the hydroxyl groups on the heavy chains of the Ab. 

Except for amines (Experiment 52G), which are easily detected by their solubility behavior, all compoimds issued in this experiment will contain heteroelements (N, S, Cl, Br, or I) only as secondary functional groups. These will be subsidiary to some other important functional group. Thus, no alkyl or aryl halides, nitro compounds, thiols, or thioethers will be issued. However, some of the unknowns may contain a halogen or a nitro group. Less frequently, they may contain a sulfur atom or a cyano group. 

Isonitrile 19 was detected in ultraviolet (UV) and infrared (IR) studies at low temperatures. They speculated that azirine intermediate 21 may precede the formation of 19 and, indeed, LFP studies on 18 performed by Richard and co-workers allowed observation of an intermediate which was assigned to 21 on the basis of the similarity of its UV absorption spectra to that of the cyclohexadienone chro-mophore. The reaction was not quenchable by piperylene and is presumed to occur via the singlet manifold. The authors did not put forward a mechanism for the formation of 21, although it may be formed by initial ESIPT from the phenol to the cyano group to give tautomer 22, which can then rearrange to give 21. Similar products (substituted benzoxazoles) were observed via presumed initial ESIPT in structurally related o-hydroxy substituted aromatic oximes and oxime ethers. ... 

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