Cutaneous lymphocyte antigen

CK Creatine phosphokinase CKMB The myocardial-specific isoenzyme of creatine phosphokinase Cl The chemical symbol for chloride CL Chemiluminescent CLA Cutaneous lymphocyte antigen CL18/6 Anti-ICAM-1 monoclonal antibody... 

Abernathy-Carver KJ, Sampson HA, Picker LJ, Leung DYM Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen. J Clin Invest 1995 95 913-918. 

Fuhlbrigge, R. C., J. D. Kieffer, D. Armerding, and T. S. Kupper. 1997. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature 389 978-981. 

Cytotoxic CD8 cutaneous lymphocyte antigen (CLA)" T cells may have a cmcial role in the pathogenesis of vitiligo, and the presence of melanocyte-specific CD8 CLA T cells seems to be closely related to the activity of the disease as the presence of this type of cells is associated with melanocyte destruction [123]. There are some studies reporting a good correlation between the clinical recovery and the modulation of CD8 CLA" T-cell number in peripheral blood after PUVA (25% reduction of CD8 CLA" T cells in comparison with pretreatment levels). This finding reinforces the therapeutic potential of PUVA treatment [124]. 

Akdis M, Simon H-U, Weigl L, Kreyden 0, Blaser K, Akdis CA Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis. J Immunol 1999 163 466-475. 

The peripheral blood of individuals with atopic dermatitis has higher numbers of cutaneous lymphocyte-associated antigens (CLA)+CD8+ T cells, which produce TH2 cytokines. 

Studies on chemokines such as CCL27 associated with skin-homing of T cells, and cutaneous lymphocyte-associated antigen CLA, are promising markers for aiding efforts to understand the relationship between T cells, drugs, and adverse delayed skin reactions. 

Santamaria Babi LF, Picker LJ, Perez Soler MT, et al. Circulating allergen-reactive T ceUs from patients with atopic dermatitis and aUergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen. J Exp Med. 1995 181 1935 0. 

PUVA is most useful for the treatment of severe psoriasis. Early (patch and plaque) stage cutaneous T-cell lymphoma (CTCL) also responds to PUVA therapy. In addition, patients in advanced stages of CTCL have been treated with a modification of PUVA known as extracorporeal photopheresis. In this therapy, blood from a CTCL patient who has taken psoralen is exposed to UVA light and returned to the patient. Lymphocytes are altered or destroyed by the treatment, and theoretically, the return of these abnormal cells triggers an immune response directed against certain lymphocyte surface antigens. The effectiveness of this modality appears to be variable. 

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