Cutaneous lymphocyte-associated antigen

Akdis M, Simon H-U, Weigl L, Kreyden 0, Blaser K, Akdis CA Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis. J Immunol 1999 163 466-475. 

The peripheral blood of individuals with atopic dermatitis has higher numbers of cutaneous lymphocyte-associated antigens (CLA)+CD8+ T cells, which produce TH2 cytokines. 

Studies on chemokines such as CCL27 associated with skin-homing of T cells, and cutaneous lymphocyte-associated antigen CLA, are promising markers for aiding efforts to understand the relationship between T cells, drugs, and adverse delayed skin reactions. 

Santamaria Babi LF, Picker LJ, Perez Soler MT, et al. Circulating allergen-reactive T ceUs from patients with atopic dermatitis and aUergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen. J Exp Med. 1995 181 1935 0. 

Abernathy-Carver KJ, Sampson HA, Picker LJ, Leung DYM Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen. J Clin Invest 1995 95 913-918. 

Pierard-Franchimont C, Letawe C, Nikkels AF, et al. Patterns of the immunohistochemical expression of melanoma-associated antigens and density of CD45R0+ activated T-lymphocytes and LI-protein-positive macrophages in primary cutaneous melanomas. Int J Mol Med. 1998 2 721-724. 

Cytotoxic CD8 cutaneous lymphocyte antigen (CLA)" T cells may have a cmcial role in the pathogenesis of vitiligo, and the presence of melanocyte-specific CD8 CLA T cells seems to be closely related to the activity of the disease as the presence of this type of cells is associated with melanocyte destruction [123]. There are some studies reporting a good correlation between the clinical recovery and the modulation of CD8 CLA" T-cell number in peripheral blood after PUVA (25% reduction of CD8 CLA" T cells in comparison with pretreatment levels). This finding reinforces the therapeutic potential of PUVA treatment [124]. 

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