Curated classification

The SCOP database is curated manually, with the objective of placing proteins in the correct evolutionary framework based on conserved structural features. Two similar enterprises, the CATH (class, architecture, topology, and homologous superfamily) and FSSP (/old classification based on structure-structure alignment of proteins) databases, make use of more automated methods and can provide additional information. 

Additionally the curated database that includes functions likely for particular genes is occasionally discovered to be inaccurate. These errors can propagate through the database, as a gene incorrectly identified by its initial discoverer is used as a model in data mining, and all similar sequences are classified as having a similar function. If the initial identification is incorrect so will be the subsequent classifications. 

Universal Protein Knowledgebase (UniProt). European Bioinformatics Institute (EBI), Swiss Institute of Bioinformatics (SIB), Protein Information Resource (PIR), Georgetown Univ. URL http //www.uniprot.org. Central repository of protein sequence and function created by joining the information contained in Swiss-Prot, TrEMBL, and PIR. A central access point for extensive curated protein information, including function, classification, and cross-reference. 

A much more ambitious database that builds on the IUBMB classification is BRENDA, maintained by the Institute of Biochemistry at the University of Cologne. In addition to the data provided by the ENZYME database, the BRENDA curators have extracted a large body of information from the enzyme literature and incorporated it into the database. The database format strives to be readable by both humans and machines. The categories of data stored in BRENDA comprise the EC-number, systematic and recommended names, synonyms, CAS-registry numbers, the reaction catalyzed, a list of known substrates and products, the natural substrates, specific activities, KM values, pH and temperature optima, cofactor and ion requirements, inhibitors, sources, localization, purification schemes, molecular weight, subunit structure, posttranslational modifications, enzyme stability, database links, and last but not least an extensive bibliography. Currently, BRENDA holds entries for approximately 3500 different enzymes. 

Just as Byzantine law preserved the Classical Roman definition of guardianship and most of its system of tutda classifications, so too it accepted the age limits assigned by the Classical jurists to the two stages of guardianship, tutda and cura. Justinian s Institutes clearly restated the Roman ages for the sixth-century Byzantine Empire. Tutors supervised boys until they reached the age of fourteen, girls until they reached the age of twelve. Thereafter, curators oversaw youths of both sexes until their wards turned twenty-five. ... 

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