SCOP database

The SCOP database is curated manually, with the objective of placing proteins in the correct evolutionary framework based on conserved structural features. Two similar enterprises, the CATH (class, architecture, topology, and homologous superfamily) and FSSP (/old classification based on structure-structure alignment of proteins) databases, make use of more automated methods and can provide additional information. 

For those interested in statistics, in September 1998, there were 7657 structures deposited in the Brookhaven Protein Database (http //www.pdb.bnl.gov). These are analyzed on the scop database (http //scop.mrc-lmb.cam.ac.uk) into 435 folds, 640 superfamilies, 948 families, and 14 903 domains. There are probably about 1000 different superfamilies.35... 

When the similar approach was applied to discriminate members of a given folding class from members of all other classes in the more comprehensive SCOP database, it was shown that specific amino acid properties work differently on different folding classes... 

Andreeva, A., Howorth, D., Brenner, S.E., Hubbard, T.J., Chothia, C. and Murzin, A.G. (2004) SCOP database in 2004 refinements integrate stmcture and sequence family data. Nucleic Acids Res. 32, D226-D229. 

Protein class assignments were based on SCOP database (Murzin et al., 1995), dividing the set of proteins in 31 all-aipha, 31 all-beta, 51 alpha/beta, 21 alpha+beta and 14 irregular or multi-domain. The relative secondary structure composition for each class is given below ... 

The Stractural Classification of Proteins (SCOP) database describes structural and evolutionary relationships between proteins of known structure (Lesk and Chothia, 1984 ... 

The SCOP database aims to provide a detailed, comprehensive description of the structural and evolutionary relationships between all proteins whose structures are known. 

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