Crompton studies

Recent studies by Crompton et al. have shown that oxidant stress may open a Ca-sensitive, non-selective pore in the inner mitochondrial membrane that is blocked by cyclosporin A (Crompton, 1990 Crompton and Costi, 1990). This pore opening results in massive mitochondrial swelling, dissipation of the transmembrane proton gradient and disruption of mitochondrial energy production (Crompton et al., 1992). Since mitochondria may play a role as a slow, high-capacity cytosolic calcium buffer (Isenberg et al., 1993), disruption of mitochondrial function may also contribute to calcium overload and cell injury. 

A complementary style of nationality-based tourism studies involves the direct assessment of what motivates travellers, how they behave and what they derive from their experiences. Several of these studies are comparative, while others focus on just one nationality group. The comparative studies include work that compares groups on destination image and attitudes, on motivation, on travel patterns, in communication style and on satisfaction levels (Chadee Mattson, 1996 Kozak, 2001 Kozak Neild, 1998 Reisinger Turner, 1999 Richardson Crompton, 1998 Yuan MacDonald, 1990). The nationalities compared are varied and reflect convenience samples rather than systematic research programs. They include Japanese and Americans, British and German, Korean and... 

From the outset, motivation has been an important topic of leisure and tourism study (Crompton, 1979 Dann, 1981 Galloway, 1998 Veal, 1997). Wahab (1975) suggested that the area of travel motivation is fundamental in tourism studies and basic to tourism development. Crompton (1979) observed that it is possible to describe tourist behaviour and to classify tourists but it is more difficult to answer the question why - the key factor underlying all tourist behaviour. Several researchers have seen motivation as the driving force behind all actions (Crompton, 1979 Fodness, 1994 Iso-... 

For both phases of the present study, the outcomes point to several common and notable findings. Firstly, the results from both phases of this first study indicated that the motivational dimensions of escape/relax, novelty, relationship, and self-development within the new travel career pattern approach are the most important travel motivation factors. A number of studies have endorsed and reinforced these kind of results. For example, the novelty-seeking motive has received considerable attention in tourism research since it was introduced into the tourism literature by Cohen (1972). It is one of the main forces behind all travel behaviour and has been explored in a number of empirical studies (Bello Etzel, 1985 Cohen, 1972 Crompton, 1979 Dann, 1977,1981). While novelty-seeking is a need to pursue stimulation, escape-seeking has been understood as a need to get away from over-stimulation (Iso-Ahola, 1982). Mannell and Iso-Ahola (1987) theorised that escape from routine responsibilities and stress... 

The (Z)-stilbene (6) does not form a rotaxane with dibenzo-24-crown-8 but, when the stilbene is isomerized (sensitized by benzil) to the E form, a pseudo-rotaxane is formed.Lewis and Crompton have reported that the photoacidity of the stilbene derivatives (7) and (8) is dependent on the position of the hydroxy group on the stilbene, and as a consequence the meta derivative undergoes isomerism.The influence of the nitrogen atoms on the photochemistry of the 1,4-distyrylbenzene analogue (9) and related compounds has been assessed. The photophysics and conformational analysis of the stilbene dimer (10) have been studied. Modelling of the optical properties of the stilbenophane (11) has been reported. 

Cox SS, van dtr Giezen M, Tarr SJ, Crompton MFR, Tovar J. Evidence fiom bioiirformatics, expression and inhibition studies of phosphoinositide-3 kinase signaling Giardia intestinalis. BMC Microbiol. 2006 18(6) 45. 

Judson IR, Beale PJ, Trigo JM, Aherne W, Crompton T, Jones D, Bush E, Reigner B. A human capecitabine excretion balance and pharmacokinetic study after administration of a single oral dose of C-labelled drug. Invest New Drugs 1999 17(1) 49-56. 

For other applications of DSC to studies of polymers, cfr. also Crompton [176]. 

DTA was also used to study the diffusion of Irganox 1330 through iPP. The technique has the advantage of being sensitive to low levels of stabiliser. The diffusion values obtained were in good agreement with those predicted by Pick s law [134]. For other applications of DTA to the examination of polymers, cfr. Crompton [176]. 

Crompton and Reid [113] used these procedures to study the distribution of rubber added in several laboratory preparations of high impact polystyrene containing 6 wt% of a styrene-butadiene rubber and 94% styrene, i.e., theoretical 4.1% butadiene. The results in Table 3.12 show the way in which the added unsaturation of 4.1 % butadiene distributes between the gel and soluble fractions the butadiene content of the separated gel remains fairly constant, in the 20-25% region, regardless of the quantity of gel present in the sample. As the gel content... 

Transformations of these sulphur compoxmds in the animal cell are regulated by variable concentrations of metabolites and enzymes in appropriate compartments. Thiosulphate enters cells only slowly, and studies of Crompton et al./l97 / showed that its transport to mitochondria is catalyzed by a dicarboxylate carrier. Little is known about other substrates of sulphurtrans-ferases such as thiocystine, 3-mercaptopyruvate, glutathione or lipolc acid, but presumably their translocations between subcellular compartments require active transport. Flg.1 shows a proposed model of distribution of principal sulpfaurtransferases and related enzymes, as well as some of their natural substrates. The scheme is certainly oversimplified and not complete but it represents the background of our investigations. 

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