Cozymase nucleotide

Bacterial synthesis of pyridine nucleotides may proceed somewhat differently. Hughes (421) has produced evidence for the following pathway of cozymase synthesis ... 

Coenzyme I (cozymase) acts with alcohol and some other substrates, while coenzyme II acts with glucose 6 phosphate. They are both phospho-pyridine nucleotides (119), the active group in hydrogen transfer being the pyridinium ring (120). 

Diphosphopyridine nucleotide, reduced form Adenine-D-ribose-phosphate-phosphate D-ribose-nicotinamide, reduced form Cozymase, reduced form... 

Nicotinamide-adenine-dinucleotide, NAD, di-phosphopyrUUne nudeotide, DPN, codehydrogenase I, coenzyme I, cozymase a pyridine nucleotide coenzyme involved in many biochemical redox processes. It is the coenzyme of a large number of oxidoreducta-ses, which are classified as pyridine nucleotide-dependent dehydrogenases. Mechanistically, it serves as the electron acceptor in the enzymatic removal of hydrogen atoms from specific substrates. 

Updated Entry replacing C-02663 Adenosine 5 - trihydrogen diphosphate) (5 ->5 ) ester with 3- aminocarbonyl)- 1-p-D-ribofuranosylpyridinium hydroxide inner salt, 9CL Nicotinamide adenine dinucleotide. Nadide, BAN, USAN, INN. Codehydrase I. Codehydrogenase I. Cozymase. Diphosphopyridine nucleotide. Enzopride. DPN. NAD. NSC 20272. Co I. NAD ... 

Coenzyme /. A heat-stable, dialyzable substance occurs in yeast and muscle tissue which is essential for the in vitro fermentation of sugars by yeast extract. Concurrent work in the laboratories of Warburg, Christian, and Griese, and Euler and Schlenk (137) established the following formula for coenzyme I (also known as cozymase, codehydrogenase I, or diphospho-pyridine nucleotide (DPN) ... 

In 1931 Otto Warburg discovered that the oxidation of glucose 6-phosphate in red blood cells required both an enzyme and a heat stable coenzyme, and he later referred to the latter as the Wasserstolfubertragendes Co-Ferment , i> to distinguish it from cozymase, the coenzyme of yeast fermentation, which had been discovered many years earlier by Sir Arthur Harden. He found that the functional group in both coenzymes was nicotinamide, which acted as acceptor for the protons removed from the substrate. In addition to nicotinamide, each coenzyme also contained one adenine and two ribosyl residues, but they differed in their phosphorus content. These observations led him to name the cozymase diphosphopyridine nucleotide (DPN), and the hydrogen-transferring coenzyme tri-phosphopyridine nucleotide (TPN). ... 

NAD+ has been designated as diphosphopyridine nucleotide (DPN), coenzyme I, factor V, codehydrogenase I, Harden s coferment, cozymase I, and codihydrase. NAD+ (C21H27O14P2, molecular weight 663.4) (inner salt) is a very hydroscopic white powder and is freely soluble in water. A 1 % solution has a pH of about 2. 

NADP is known as triphosphopyridine nucleotide (TPN), coenzyme II, Warburg s coferment, codehydrogenase II, cozymase II, and phosphocozymase. NADP (C21H28N7O17P3, molecular weight 743.44) (inner salt) is a grayish-white powder. It is soluble in water and in methanol, but much less soluble in ethanol and practically insoluble in diethyl ether and ethyl acetate. 

The S -phosphates of deoxyribosyl adenine, etc. Adenosine diphosphate Adenosine triphosphate Nicotinamide mononucleotide Diphosphopyridine nucleotide (cozymase, coenzyme I)... 

Pyridine proteins, conjugates of pyridine nucleotides cozymase (co-enzyme I, or co-dehydrogenase I), co-enzyme II (codehydrogenase II). 

---