Cortisol 11-deoxy

The glucocorticoids mainly influence carbohydrate metabolism and, to a certain extent, protein and lipid metabolism (see Table 14 and Figure 55). The main glucocorticoid is cortisol, with a daily secretion of 15 mg. Cortisol is synthesized through the 11-beta-hydroxylation of 11-deoxy-cortisol. Besides cortisol, the adrenal gland also synthesizes and releases a small amount of corticosterone, whose synthesis from 11-deoxycorticosterone is catalyzed by 11-beta-hydroxylase. A deficiency of 11-beta-hydroxylase causes ... 

Figure 12 Screening of a steroid library, (a) An imprinted polymer prepared for lla-hydro-xyprogesterone. Mobile phase dichloromethane (DCM) - 0.1% acetic acid v/v, Flux 0.5mL/min. (b) An imprinted polymer prepared for lla-hydroxyprogesterone. Gradient elution, 0-25 min, DCM 0.1% acetic acid v/v 25-30 min, DCM 0.1-5% acetic acid v/v 30-40 min, DCM 5% acetic acid v/v 40-45 min, DCM 5-0.1% acetic acid v/v. Flux 0.5mL/min. (c) A control polymer prepared in the absence of template molecule. Isocratic elution, DCM 0.1% acetic acid v/v. Flux 0.5mL/min. Sample component. (1) lla-hydroxyprogesterone, (2) lla-hydroxyprogesterone, (3) 17a-hydroxyprogesterone, (4) progesterone, (5) 4-androsten-3,17-dione, (6) l,4-androstadiene-3,17-dione, (7) corticosterone, (8) cortexone, (9) 11-deoxy-cortisol, (10) cortisone, (11) cortisone-21-acetate, (12) cortisol-21-acetate. Reproduced from Ref. 58, with permission.

Deoxy cortisol Deoxycorticosterone 50J-Dihydrocortisol 1 IjS-Hydroxyprogesterone 11-Deoxy cortisol Progesterone... 

Cortexolone, Reichsteints substance S, 11-deoxy-cortisol, na-hydroxy-ll-deoxycortieosterone, 17a,-2I-dihydroxypregn-4-ene-4,20-dlone a mineralocor-ticoid from the adrenal cortex. For structure and biosynthesis, see Adrenal corticosteroids. 

Wei, J.Q. Wei, J.L. LucareUi, C. Zhou, X.T. Wang, D.Q. Dai, W.J. Li, S. Li, S.M. Liu, R.T. Serum steroid hormonal profiles by reversed-phase liquid chromatography in patients with 17-hydroxylase deficiency and in an affected family, Clin.Chem., 1992, 38, 76-82. [cortisone hydrocortisone deoxy-cortisol androstenedione testosterone progesterone hydroxyprogesterone desoxycorticosterone]... 

The mechanism of ll hydroxylation has been examined by tracer techniques using both deuterium and oxygeu-18. No deuterium is introduced into the product when the hydroxylation (of 11-deoxy-cortisol) is carried out in D2O (335). This observation rules out mechanisms of hydroxylation in which dehydrogenation is followed by hydration, as in the prototype succinate-fumarate-malate. In confirmation of this, A -unsatiuated analogues of deoxycorticosterone are not hydroxylated by mitochondrial preparations (335). When enzymic hydroxylation is carried out in media enriched with 0 , it is found that the oxygen of the 1 l-hydroxysteroids is derived from molecular oxygen (336,724) (Table XIV). The same results have been obtained in hydroxylations carried out by microorganisms (Table XV) (72,337). 

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