Coronary artery disease, treatment

Non-alcohol steatohepatitis Fat build-up in the liver eventually causes scar tissue associated with diabetes, protein malnutrition, obesity and coronary artery disease. Treatment with corticosteroid medications. Biopsy is needed for full diagnosis. 

Coronary artery disease Treatment with nitrates and calcium antagonists, which decrease the LES pressure detection bias with chest pain evaluation... 

Presently, only adenosine itself is approved for clinical use. It is used widely in the treatment of supraventricular tachycardia and in cardiac stress imaging to assess coronary artery disease [5]. Other agonists and antagonists and an allosteric modulator of the Ai receptor are in clinical trials for a variety of indications. 

Low levels of vitamin E have been associated with increased incidence of coronary artery disease. Observational studies have therefore suggested that supplemental a-tocopherol might have value in the treatment of cardiovascular disease. Clinical studies demonstrated contradicting results regarding the benefits of vitamin E in the prevention of cardiovascular disease. Four... 

In 1998 the REGRESS group published data, which showed that the TaqlB polymorphism in intron 1 of the cholesterol-ester transfer protein (CETP) gene predicts whether men with coronary artery disease would benefit from treatment with pravastatin or not [60]. Pravastatin therapy slowed the progression of coronary athero-... 

Aspirin (acetylsalicylic acid) (Figure 29.21) is a widely applied drug for reducing ischemic cardiovascular events in patients with coronary artery disease, hypertension, or at cardiovascular risk. It is believed that the main protective function of aspirin is the inhibition of cyclooxygenase however, it has been recently proposed that aspirin may possess additional antioxidant activity [348]. It was found that long-term aspirin treatment of normotensive and hypertensive rats resulted in a decrease in vascular superoxide production by the inhibition of NADPH oxidase activity. 

Coronary artery disease Due to the vasodilatory effect of dipyridamole, use with caution in patients with severe coronary artery disease (eg, unstable angina, recently sustained Ml). Chest pain may be aggravated in patients with underlying coronary artery disease who are receiving dipyridamole. For stroke or transient ischemic attack patients for whom aspirin is indicated to prevent recurrent Ml or angina pectoris, the aspirin in this product may not provide adequate treatment for the cardiac indications. 

Sdringola S, Nakagawa K, Nakagawa Y, Yusuf SW, Boccalandro F, Mullani N et al. Combined intense lifestyle and pharmacologic lipid treatment further reduce coronary events and myocardial perfusion abnormalities compared with usual-care cholesterol-lowering drugs in coronary artery disease. J Am Coll Cardiol 2003 41 263-272... 

Favalaro RG. Saphenous vein graft in the surgical treatment of coronary artery disease operative technique. J Thorac Cariovasc Surg 1969 58 178. 

Parisi AF, Folland ED, Hertigan P. A comparison of angioplasty with medical therapy in the treatment of single-vessel coronary artery disease. N Engl J Med 1992 326 10. 

Waller BF. Crackers, breakers, stretchers, drillers, scrapers, shavers, burners, welders and melters —the future treatment of atherosclerotic coronary artery disease a clinical-morphologic assessment. J Am Coll Cardiol 1989 13 969-987. 

Fischman DL, Leon MB, Bairn DS, et al., for the Stent Restenosis Study Investigators. A randomized comparison of coronary stent placement and balloon angioplasty in the treatment of coronary artery disease. N Engl J Med 1994 331 496-501. 

Schoebel, F. et al. (1997). Antithrombotic treatment in stable coronary syndromes—long-term intermittent urokinase therapy in end-stage coronary-artery disease and refractory angina pectoris. Heart 77(1), 13-17. 

Older patients have predominantly Type 2 diabetes mellitus, which shares with Type 1 the risk for retinopathy, nephropathy and neuropathy, but carries a greater risk for macrovascular complications such as coronary artery disease, stroke and peripheral vascular disease. Many such patients have associated obesity, hypertension and hyperlipidemia, compounding the risk of cardiovascular disease. The goals of treatment of DM in the elderly are to decrease symptoms related to hyperglycaemia and to prevent long-term complications. Treatment of type 2 DM can improve prognosis. In the UKPDS trial, sulphonylureas, insulin, and metformin were all associated with a reduction in diabetes-related... 

Aside from sildenahl, apomorphine is one of the few orally active (buccal route) pharmacological agents used in the treatment of ED. Apomorphine stimulates penile erection in both normal men and in men who are impotent. Apomorphine can be the drug of choice in patients with coexisting benign prostatic hyperplasia (BPH), coronary artery disease, and hypertension. 

Unlabeled Uses To increase survival rate in diabetic patients with coronary artery disease (CAD) treatment orprevention of anxiety cardiacarrhythmias hypertrophiccar-diomyopathy mitral valve prolapse syndrome pheochromocytoma tremors thyrotoxicosis vascular headache... 

Simvastatin is also used in combination with nicotinic acid. It is found to be the most useful drug combination for the treatment of dyslipidemias associated with coronary artery disease. It is particularly effective in normalizing the lipid profiles of patients with familial combined dyslipidemia. 

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