Morphologic assessment

Bhawan J, Andersen W, Lee J, Labadie R, Solares G (1995) Photoaging versus intrinsic aging a morphologic assessment of facial skin. J Cutan Pathol 22 154-159... 

Waller BF. Crackers, breakers, stretchers, drillers, scrapers, shavers, burners, welders and melters —the future treatment of atherosclerotic coronary artery disease a clinical-morphologic assessment. J Am Coll Cardiol 1989 13 969-987. 

Between about 3 and 4 dpf, larval movements and increasing tactile responsiveness necessitate anesthesia of larvae when detailed morphological assessments are performed. A 0.003% Tricaine solution is effective. 

Viability and embryo lethality are recorded for the respective treatment but only viable embryos undergo morphological assessment. The criteria for defining embryo lethality include one or more of the following ... 

The integrity of the somite borders and general size and shape of the somites are assessed throughout the axis. The last 1-2 pairs of somites are newly formed, or in the process of forming, and are not considered in the morphological assessment, since any anomalies may be transient in nature. 

The facial region is morphologically assessed for developmental integrity of the nasal prominence, optic and otic placodes, as well as the relative spatial distance between the placodes as it pertains to the formation of the mesencephalic flexure (Fig. 13). 

Breast cancer patients with the same stage of disease can have markedly different clinical outcomes. Traditional diagnostic and prognostic factors may stratify patients with molecularly distinct diseases into the same group based on morphological assessments. It remains a critical issue to reliably identify specific breast cancer patients at high risk for recurrent and metastatic disease. Molecular prediction is the future direction of personalized cancer care. 

Banks, W.A., and R.D. Broadwell. 1994. Blood to brain and brain to blood passage of native horseradish peroxidase, wheat germ agglutinin, and albumin Pharmacokinetic and morphological assessments. J Neurochem 62 2404. 

Middleton MC, Pratt I. 1978. Changes in incorporation of [3H]thymidine into DNA of rat skin following cutaneous application of dibutyltin, tributyltin and 1-chloro-2 4-dinitrobenzene and the relationship of these changes to a morphological assessment of the cellular damage. J Invest Dermatol 71 305-310. 

FIGURE 4 Morphological assessment of liposome surface coating using cryo-TEM. Liposomes that have been conjugated with transferrin display small particles on their surface (a), while control preparations appear to be smooth and undecorated ( >). (Reproduced from ref. 73 with permission of Elsevier.)... 

It is of paramount importance for the morphological assessment of cirrhosis to know whether the liver material was obtained by (1.) post-mortem autopsy (when lymphohistiocytic inflammatory reactions are hardly detectable anymore) or (2.) biopsy with the aid of a Menghini needle (which only rarely yields fully assessable cirrhotic material). In contrast, biopsies carried out with a Silverman needle, for example, produce an adequately sized biopsy cylinder for assessment. 

Most model systems in ototoxic research are geared towards drugs that cause permanent hearing loss, most relevantly cisplatin or AG antibiotics. Therefore, they focus on the functional or morphological assessment of hair cells as the primary targets of these ototoxins. 

In addition to morphological assessments of crystals, optical microscopy can be used to measure their refractive indices. To identify the crystal, it is not necessary to measure the principal refractive indices simply measuring two that are unique and reproducible is sufficient. These are termed the key refractive indices that, according to these researches, are all that are needed to identify any particular compound. 

Not all cells expose PS—this needs to be confirmed for each cell type need live cell culture or unfixed specimens doesn t work as well for adherent cells does not work at all for fixed cells or tissues necrotic cells will also stain positive and will require morphologic assessment or combination assay (see below)... 

Roy, T. S Sharma. V, Seidler, F, J and Slolkin. T, A, (2005), Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic expo.sure to chlorpyrifos in neonatal rats. Dev. Brain Res.. 155, 71-80,... 

A surface morphology assessment and a study of the failure were both performed with a Hitachi S 3000 N scanning electron microscope (SEM) without surface metaUization prior to observation, at a magnification ranging from 30 x to 2500 X. 

The lymphocyte transformation test, first proposed as a morphological assessment of lymphoblast production in culture upon incubation with the antigenic drug (Heitmann and Kuwert 1966 Halpern et al. 1967), was soon used in its biochemical version, based on measurement of DNA synthesis and [ HJthymidine uptake (Rose et al. 1966 Vischer 1966 Evans 1967 Fellner et al. 1967 a Assem and Vickers 1972 Sarkany and Gaylarde 1978 Warrington and Tse 1979). Al-... 

We demonstrated the detection of DOX-related glomerular injury using desmin as a sensitive podocyte injury marker in the subacute nephrotoxicity in rats. The fully automated image analysis platform could feasibly support morphologic assessment of compound-induced glomerulopathy in bespoke discovery toxicology studies and/or retrospective analysis. 

Dardik H, Ibrahim IM, Dardik I. Modified and unmodified umbilical vein allografts and xenografts employed as arterial substitutes a morphologic assessment. Surg Forum 1975 26 286-7. 

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