Control item

Depth measurement possibility on complex-contour parts (in the corners, grooves etc.) by training the device in the dialog mode on control items with certain depth cracks... 

The compressor manufacturer can control items a-c, e, f, and h however, the control of clearance volume at high compression ratios for gases/vapors with low specific heat ratios is of great concern. Compression efficiency is controlled by the clearance volume, valves, and valve pocket design. A decrease in compression efficiency leads to increased power requirements. ... 

SPICE tip The optimizer function of the SPICE simulators is tailor made for this problem. The optimization feature can be performed in Micro-Cap by using the STEPPING feature in the AC menu, and in PSpice by using the PARAMETRIC sweep in the setup dialog box. In IsSpice, the OPTIMIZER sweep menu is selected by selecting the SIMULATION CONTROL item in the ACTIONS menu of ICAP. 

Equipment systems are available that will, periodically during the day or week, activate two pumps to add a prescribed volume of each of these two chemicals into a mixing tank. The tank contents are stirred, HOBr is produced, and the tank contents are then pumped to the cooling water system. Such systems can also incorporate bromine monitors and chart recorders, plus other dosing and control items. 

The first four items listed above are directly related to the manufacture and validation of solid dosage forms. Items 1 and 3 are normally associated with variability in the manufacturing process, while items 2 and 4 are usually influenced by the selection of the ingredients in the product formulation. With respect to content uniformity and unit potency control (item 3), adequacy of mixing to assure uniformity and homogeneity is considered a high-priority concern. 

As the first step in implementing any controlled change on a computer system, the scope of work should be determined and documented. This will provide a comprehensive list of all controlled items, as well as any uncontrolled items that require modification as part of the change. This should include ... 

All control items in the loop, including loop controllers and computerized eontrol system I/O card address and termination details the I/O details would need to be provided by the computerized control system designers... 

Key words In vitro method, Test method, Validation, Test system, Reference item, Control item,... 

Reference item ( control item ) means any article used to provide a basis for comparison with the test item [3]. 

An example of an experimental 96-well plate layout using these reference and control items is shown in Fig. 1. 

The inclusion of relevant reference and control items, and setting of acceptance criteria on basis of historical data, is essential for regulatory applicability of in vitro methods. By including the correct... 

Control items are used to control the proper performance of the test system [8 ]. Monitoring and recording performance against negative and positive control items may constitute sufficient proof for the responsiveness of a given test system. Non-response of the test system to the negative control and response to the positive control, within the acceptance criteria, show that the test system is reactive and behaves as expected. 

For positive, negative, and vehicle control items (in those cases where the negative control is different from the solvent control), it may or may not be necessary to determine concentration and... 

The positive control item is one that has an impact on the in vitro test system. It is often used to assess aspects such as the characteristics of the test system and if the in vitro methods gives reliable results for this positive control over time in accordance with historical data. Moreover, a positive control, that meets the predefined acceptance criteria, assures that when a test item has no effect on the in vitro method that the negative result is not caused by an error during the testing phase. Therefore, the results from the control test items are of outmost importance to show that a valid run has been performed when test data for each unknown test item are submitted to regulatory authorities. 

Acceptance criteria for reference items, positive, negative and vehicle control items (e.g., purity, known response, cytotoxicity) should be developed and detailed in the SOP. 

The G.P. chamber is equipped with an air cooler of about 5500 BTU size (Item 3) is located about 1.8 meters off the floor. An evaporator control valve (Item 2) on the refrigerate line allows temperature control of the air cooler condenser coils. Temperature of the coils is maintained just above the dew point for 50% relative humidity. An electric baseboard heater (Item 6) is equipped with a hydrastatic thermostat control (Item 11). The base board heater is placed near the floor and opposite of the chamber door. A humidifier (Item 4) is located approximately 1.8 meters above the floor and just to the right of the air cooler. The nozzle of the humidifier is pointed slightly toward the back of the chamber. A humidistat (Item 10) is centered between the floor and end walls on the same side as the humidifier. A strategically located recording hygrothermograph is used to monitor both temperature and humidity. 

The second point can be considered a semantic one, and it relates to the definition of the test and reference item. In all those cases, where the test item is applied in a vehicle, the respective vehicle may also be applied to the test system in the property of the reference (or control) item, and therefore, a sample of the vehicle should then also be retained. In the case of toxicity studies involving the admixture of the test item to the feed, the feed therefore becomes the reference item, and thus samples of the respective feed batches will have to be retained for analytical purposes , e.g. for later ascertainment that the reference feed did neither contain traces of the test item, nor that it was contaminated in any other way which could have influenced the study. 

When all steps of the method have been developed, optimised and verified, the analyst has to combine the procedure and work out quality control items for routine use which may allow him to investigate a posteriori that the method is still under control. The control... 

Topological consistency Where the physical location of the controlled items is important, the layout of dials should reflect their geographical arrangement. 

At present, only a postmonitoring interview can reveal such effects, but this evaluation can be rather difficult. Little is known about whether it is advisable to include a few control items and questions in the computer-assisted questionnaire that directly refer to actual (non-) compliance, noncompliance, and method-dependent effects, for example, the subject s being irritated by the beeps or having specifically changed the usual routine. 

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