Contact allergy clinical aspects

The most frequent manifestations of drug allergy involve the skin. Urticaria, angioedema, exanthematous skin rashes, allergic eczematous contact dermatitis, photodermatitis, fixed drug eruptions, erythema multiforme, and the Stevens-Johnson and Lyell syndromes are the best characterized clinical manifestations. Their clinical aspects, evolution, and pathophysiological mechanisms are described in detail in the following chapter. 

In recent years, the clinical aspect of contact allergy has broadened, as our understanding of pathogenetic mechanisms has improved, concomitant with more frequent use of patch testing. Besides the classical allergic contact dermatitis, new clinical entities representing unexpected morphology and different pathomecha-nisms have arisen ... 

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