Considerations when applying

The following considerations, when applied during method development, are likely to produce more robust, reliable, and transferable methods (a) the concerns of the customer (user) are considered in advance, (b) key process input variables are identified, (c) criticaTto-quality factors are determined, (d) several method verification tests are installed, (e) proactive evaluation of method performance during development is performed, (f) continuous customer involvement and focus are institutionalized, and (g) method capability assessment (suitability to be applied for release testing against specification limits) is established. 

In conclusion, the IBTFA-mediated Hofmann rearrangement is the most convenient method for the synthesis of the N-acylated gem-diaminoalkyl derivatives and is certainly the most frequently used procedure for the generation of peptidyl gem-diaminoalkyl derivatives. However, as mentioned above, this method has limitations with regards to the choice of protecting groups and therefore requires careful consideration when applied to amino acids with reactive side chains. 

All the previously cited models and works also consider, and some explicitly cite, this assumption—that the catalyst activity varies with time-on-stream (or with coke concentration [12]) in the same manner or with the same deactivation function (VO for all reactions in the network. That is, a nonselective deactivation model is always used. Corella et al. (16) have recently demonstrated that in the FCC process this assumption is not true and that it would be better to use a selective deactivation model. Another work (17) also shows how this consideration, when applied to catalytic cracking, influences the yield-conversion curves. Nevertheless, to avoid an additional complication, we will use in this chapter a nonselective deactivation model with the same a—t kinetic equation and deactivation function (VO for all the cracking reactions of the network. 

A similar consideration when applied for the stirrer led via the tangential velocity of the liquid on the outer edge of the stirrer to the sought relationship for the power number of the stirrer... 

Hallen D, Data-treatment Considerations when applying binding reaction data to a model. Pure Appl. Chem. 1993 65 1527-1532. 

Procurement of items must be at the most appropriate level in order to obtain the best value for money while ensuring the quality of the product and the supply chain. This level will vary according to local/national policies. It will include consideration of the most appropriate Stock Turn for the individual items. A Stock Turn is the rate at which a company s goods are sold and replaced. With main fine stock there should be a turnover of around five or six times a year. However in pharmacies there are a number of medicines which require different considerations when applying stock control principals. The medicines in these categories may never be used but it is essential to have them available if needed. Therefore, for these medicines the concept of a Stock Turn will not apply. However, if possible. 

For further simplifications, one may note that for small values of the argument, it is possible to neglect higher order terms in an exponential series and approximate exp(jc) as I+x. This consideration, when applied to the potential distributions depicted by Eqs. (12a), (12b), forms the basis of the Debye-Huckel linearization principle [2], which effectively linearizes the pertinent exponential variation of ionic charge distribution for small values of e /k T. Under such approximations, Eq. (13) can be simplified as... 

Sintered density is an important consideration when applying steam treating for improved strength and hardness. Its ability to increase the wear resistance of the substrate material depends on the available porosity for oxidation. As density is increased, the amount of oxide formed is... 

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