Conditioned place aversion

HT3 antagonist Reduced withdrawal-induced conditioned place aversion Suzuki et al. (1997)... 

Early adolescent smoking onset is a risk factor for severe addiction and difficulty in smoking cessation in adulthood (Breslau and Peterson 1996). Therefore, it is significant that nicotine has more potent rewarding effects in adolescent as opposed to adult rodents (Adriani et al. 2004 Belluzzi et al. 2004 Vastola et al. 2002). However, several studies suggest that adolescent rodents develop physical nicotine dependence less readily than adults, as indicated by less severe nicotine withdrawal syndrome. Unlike adult rats, continuously nicotine-infused adolescent rats failed to display mecamylamine-precipitated withdrawal behaviors (O Dell et al. 2004, 2006). They also displayed less mecamylamine-precipitated conditioned place aversion than adults (O Dell etal. 2007). In addition, nicotine-infused adolescent rats experienced smaller mecamylamine-precipitated ICSS threshold elevations than adults (Kota et al. 2007). Nicotine-infused adolescent mice also displayed fewer spontaneous and mecamylamine-precipitated somatically expressed withdrawal behaviors... 

Frisch, C., R. U. Hasenohri, C. M. Mattern, R. Hacker, and J. P. Huston. Blockade of lithium chloride-induced conditioned place aversion as a test for antiemetic agents comparison of metoclopramide with combined extracts of Zingiber officinale and Ginkgo biloba. Pharmacol Biochem Behav 1995 52(2) 321-327. 

NEURONAL MECHANISMS FOR PAIN-INDUCED AVERSION BEHAVIORAL STUDIES USING A CONDITIONED PLACE AVERSION TEST... 

Pain is comprised of sensory discriminative and negative affective components. Although the neural systems responsible for the sensory component of pain have been studied extensively, the neural basis of the affective component is not well understood. Recently, behavioral studies using the conditioned place paradigm have successfully elucidated the neural circuits and mechanisms underlying the negative affective component of pain. This review focuses on the behavioral studies that have used conditioned place aversion (CPA) tests to elucidate the neuronal mechanisms underlying pain-induced aversion. 

Suzuki et al. (1991, 1993) and del Pozo et al. (1996) studied opioid-induced place preference in and Bechtholt et al. (2004) studied the effects of handling on conditioned place aversion and conditioned place preference by ethanol in mice. 

Acquas E, Carboni E, Garau L, Di Chiara G (1990) Blockade of acquisition of drug-conditioned place aversion by 5-HT3antagonists. Psychopharmacology 100 459 163 Amalric M, Cline EJ, Martinez JL Jr, Bloom FE, Koob GF (1987) Rewarding properties of P-endorphin as measured by conditioned place preference. Psychopharmacology 91 14-19... 

Martin-Iverson MT, Reimer AR, Sharma S (1997) Unbiased cocaine conditioned place preferences (CPP) obscures conditioned locomotion, and nimodipine blockade of cocaine CPP is due to conditioned place aversions. Psychopharmacology 130 327-333... 

Schechter MD, Meehan SM (1994) Conditioned place aversion produced by dopamine release inhibition. Eur J Pharmacol 260 133-137... 

Di Scala G, Sandner G (1989) Conditioned place aversion produced by FG 7142 is attenuated by haloperidol. 

Besides the CPP test, which is based on the rewarding properties of a drug, a conditioned place aversion (CPA) test is also often described in the literature (Cunningham et al., 2006). In the latter, rats will spend less time in the drug-paired compartment at posttest. A CPA is often related but not limited to drugs that produce aversive effects. Examples hereof described in the literature include naloxone (Cunningham et al., 2006) and lithium chloride (Prus et al., 2009). 

CPA conditioned place aversion HTS high-tooughput screening... 

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