Conditional knockout mice

Most importantly, later genetic experiments, using conditional knockout technique to delete all forms of CREB in either the entire forebrain or hippocampus, showed that these conditional knockout mice have normal hippocampal early- and late-phase LTP, and normal performance in hippocampal-dependent memory tasks [13]. Therefore, those newer findings cast significant doubt on the role of CREB as a central switch for long-term plasticity. 

Integrin betal null platelets from conditional knockout mice develop normally, platelet count is normal. Collagen induced platelet aggregation is delayed but otherwise normal tyrosine phosphorylation pattern is normal but phosphorylation is delayed. Bleeding time in bone marrow chimeric mice is normal no major in vivo defects (Nieswandt et al. 2001). 

Rojek A, Fuchtbauer EM, Kwon TH, Frokiaer J, Nielsen S Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice. Proceedings of the National Academy of Sciences of the United States of America 103 6037-6042,2006... 

To further dissect CRH/CRHRl central nervous system pathways modulating behavior from those regulating neuroendocrine function, a region-specific, conditional knockout mouse line CaMKII Cre) was generated... 

RATIONALE FOR A CONDITIONAL KNOCKOUT MOUSE MODEL TO STUDY CARNITINE PALMITOYLTRANSFERASE I DEFICIENCIES... 

The outcome of a CPTIB knockout study will provide answers to existing questions. It can be e qiected that new questions will arise as well, and that basic scientific insight may gain considerably. One of the major reasons to develop a conditional knockout mouse model for both CPTl genes is to investigate the phenotype of a M-CPTl defect as a single entity, as well as in conjunction with a L-CPTl defect. 

The ability to selectively modify the genome In the mouse has revolutionized mouse genetics. Outline the procedure for generating a knockout mouse at a specific genetic locus. How can the loxP-Cre system be used to conditionally knock out a gene What Is an Important medical application of knockout mice ... 

CYP27B1 knockout mice have been characterized and show a typical rickets phenotype. Another mouse model in which the gene has been ablated showed skeletal, reproductive, and immune dysfiinction. Rickets was also observed in a conditional knockout model . ... 

Conditional Knockout of HIF-la in a Mouse Model of Breast Cancer Reveals that HIF-la Is a Key Mediator of Metastasis... 

Since L-CPTl deficiency is compatible with life, it is anticipated that a CPTIA knockout mouse model will be a viable model system. The value of such an animal model will increase if conditional (spatiotemporal) control of L-CPTl function can be achieved... 

---