Compound discovered

Alkali Metal Perchlorates. The anhydrous salts of the Group 1 (lA) or alkah metal perchlorates are isomorphous with one another as well as with ammonium perchlorate. Crystal stmctures have been determined by optical and x-ray methods (38). With the exception of lithium perchlorate, the compounds all exhibit dimorphism when undergoing transitions from rhombic to cubic forms at characteristic temperatures (33,34). Potassium perchlorate [7778-74-7] KCIO, the first such compound discovered, is used in pyrotechnics (qv) and has the highest percentage of oxygen (60.1%). 

Among some 70 new antitumor compounds discovered by H. Umezawa and coworkers, formycin (1966) constituted another important discovery. Produced in conjunction with coformycin, the latter inhibits the activity of adenosine deaminase (1967) and enhances the antitumor activity of formycin. 

Compadre, C. M., Pezzuto, J. M., Kinghorn, A. D. and Kamath, S. K. 1985. Hernandulcin an intensely sweet compound discovered by review of ancient literature. Science 227 417 19. 

Development of the chemistry of metal carbenes commenced with the characterization of complexes such as (CO)sW=C(OMe)Ph by Fischer and his co-workers (e.g., Ref. 14 and references therein). The series of hydrocarbon-substituted carbene compounds discovered later by the Schrock group (e.g., Ref. 15 and references therein) appeared to be so different from the other known carbene complexes that they were placed in a different class altogether. Overemphasis of this distinction has persisted in the literature of carbene complexes, even to the present day. 

Few known and thermodynamically feasible molecular structures are presently seen as impossible goals for synthesis. New transformations and effective strategies permit chemists to synthesize highly complex molecules, such as new natural compounds discovered in the continued chemical exploration of the natural world. Again, the point of such work is to develop new chemistry that permits an approach to structures of the type found in nature. This expands the power of chemistry and allows medicinal chemists to synthesize complex structures. 

Golebiowski, A., Klopfenstein, S.R., and Portlock, D.E. Lead compounds discovered from libraries Part 2. Curr. Opin. Chem. Biol. 2003, 7, 308-325. 

Golebiowski A, Klopfenstein SR, Portlock DE Lead compounds discovered from libraries part 2. Curr Opin Chem Biol 2003, 7, 1-18. 

Dissolving metal reductions were among the first reductions of organic compounds discovered some 130 years ago. Although overshadowed by more universal catalytic hydrogenation and metal hydride reductions, metals are still used for reductions of polar compounds and selective reductions of specific types of bonds and functions. Almost the same results are obtained by electrolytic reduction. 

A class of compounds, discovered at Ely Lilly in 1961, are the dinitroanilines, with trifluralin (Treflan ) being an important member. Trifluralin is used on soybeans and cotton. Pendimethalin is a second important dinitroaniline. Benefm is a common crabgrass preventer for home lawns. 

Phosphorus-containing iron ores are sometimes used in the steel industry, so an investigation of the Fe-P-O system at 800-1000 C has been made. Some of the new compounds discovered in this work contain mixed iron valencies. 

The term aromatic was applied to these compounds because many of the first such compounds discovered had pleasant odors. 

Table 4 Examples yf Key Compounds Discovered During StrucLure-Bajicd Design uf AG 1343 fNelfinavir)...

There have been many compounds discovered which resemble the [ReOy2- ions... 

For a long time, pentazole chemistry only involved the study of the chemical and physical properties of the pentazole compounds discovered by Huisgen and Ugi. More than 40 years later, the first pentazole attached to a five-membered ring system, tetrazolylpentazole, was reported by Hammerl and Klapotke <2002IC906>. Unfortunately, this compound decomposes below — 50 °C. Imidazolylpentazole is reported to be stable up to — 30 °C. Recently, the first dipentazole, l,4-bis(/>-pentazolyl)butane, has been observed by nuclear magnetic resonance (NMR) spectroscopy <2004ZNB716>. 

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