Compositional SAR

Silica Oxide to Alumina Oxide Ratio (SAR) is used to describe the framework composition of zeolite. 

P. A. Methods and Compositions for Inhibiting SARS-Related Coronavirus Replication by Using Inhibitors of SARS-Related Coronavirus 3C Proteinase. World Patent W02004093860, November 11, 2004. 

The 10 best polymers were reprepared in larger amounts to confirm their properties, and each preparation was repeated twice to check if the random disposition of the acid-derived functional groups on the polyamine backbone was influencing the reducing efficiency. All the polymers were confirmed as active, and the two batches showed comparable activities, confirming the reproducibility of this synthetic method. Several crude indications in terms of SAR were identified, and a structural specificity of reducing efficiency was clearly present, albeit difficult to rationalize. For example, compare the activity of similar composites 11.27 (40% yield) and 11.29 (1.3% yield). Many modifications of the polymeric scaffold (different average MWs, increase of... 

First, and i3C iH NMR data confirmed the composition of the compounds isolated and a high symmetry (in most cases, C3 or Ds) of clathrochelate molecules in solution. Such symmetry has not been observed for compounds that do not have this type of symmetry a priori (in particular, for complexes with sar 2NOH or absar ligands). The iH NMR spectra of the latter, for example, exhibits three signals assigned to amino group protons [101]. 

Zeolite composition was determined by X ray fluorescence, in a XRF Phillips PW 1407 spectrometer. The fimnework silica to alumina ratio (SAR) was determined by FTIR in the structure vibration region by means of the fi uency shift of a characteristic band around 800 cm with a Nicolet 60SXR spectrometer. The textural characteristics of the zeolites, such as BET specific area, micropore volume (t-plot) and mesopore area (BJH), were evaluated by physisorption of N2 at 77K in a Micromeritics ASAP 2400 and their acid sites density by TPD of NH3 (adsorption performed at 423K with a 4.0% NH3/He mixture and TPD performed at 20K/min up to 823K). 

In general, SARs predict the toxicity of organic compounds based on their physical and chemical properties, particularly in the field of carcinogenesis. Toxicants move from the environment into the organisms, to exert their toxic action within the cells. Both processes depend on the elemental composition and stmcture of the chemical. 

Figure 15.2 illustrates some of the discovery bioactivity experiments in which a test compound must be successful to advance. If erroneous activity or selectivity data are generated or misinterpreted, the SAR will mislead the project team. SAR is a central strategy of drug-discovery research. If the activity assays are affected by properties in addition to target protein interaction, then the SAR will be a composite of multiple variables. Table 15.1 lists some of the potential effects on SAR from lack of property data application in planning and interpretation of drug-discovery bioassays. 

The typical compositional range of exchange sites in soils, shown in Figure 8.4, reveals that sodic soils have higher than normal levels of exchangeable Na" ". The important ionic concentrations in soil solution that affect the level of exchangeable Na are [Na" ], [Ca " ], and [Mg +], The sodium adsorption ratio, or SAR, is a solution property defined by the equation... 

A. S, Dimoglo, Chim. -Pharm. Zh. 19, 438 (1985). The Compositional Method of Description of the Electronic Structure of Organic Molecules Oriented to Computer Analysis of SAR (Russian). 

Surface acidify, as well as hydrophobicity of zeolites, are usually related to their composition, in particular the silica/alumina ratio (SAR). In the present descriphon, this crucial parameter will be reported between brackets at the end of fhe zeolife-fype code [es BEA(26)]. ... 

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