Components of signalling networks linkers and regulators

1 Common structural motifs, instrumental in forming interconnectivity of components in signal transduction chains. [Pg.32]

Grb2 (growth-factor-receptor-binding protein), and IRSl (insulin receptor substrate ) have related functions. [Pg.32]

One way to reduce complexity of cellular regulation is to look for conserved structural modules, present in many different regulatory proteins. These recurrent motife help [Pg.32]

Protein-protein recognition in signal transduction pathways [Pg.33]

A principal function of the phosphorylated tsrosine sites on receptors is to recruit other proteins with complementary recognition sites. These can be enzymes, such as phospholipase C, or regulatory proteins and linkers of all kinds. [Pg.33]

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