Components in drugs

Fukuda, K.,Ohra, T. 8cYamazoe,Y. (1997). Grapefruit component interacting with rat andhuman P450 CYP3A possible involvement on non-flavonoid components in drug interaction. Biol. Pharm. Bull, 20, 560-4. 

Klein, T., Friedman, H, Modulation of murine immune cell function by marijuana components, in Drugs of Abuse and Immune Function, Watson, R. CRC Press, Boca Raton, FL, 1990, pp. 87-111. 

Time-shcing is a variation of the stop-flow mode where the flow is stopped in a time-dependent manner (e.g. every 15 s) for the whole chromatographic run, in a sense the ultimate approach in slow-flow. When the flow is stopped, sufficient scans can be made to give the desired level of detection before moving on to the next time-slice. The whole process can be automated through software control. There is no requirement for an UV detector, and the approach has been used to identify non-UV-active components in drug substances [48]. The peak purity of... 

The vast majority of caffeine is ingested in a beverage such as coffee, tea, or soda. Beyond beverages, caffeine is also consumed in snacks such as chocolate candy bars, or as a component in drug medications. 

In another investigation by the author [1], poly(acrylic acid)-g-poly(lactic acid), (1), was prepared and used as a bioadhesive conjugated with biodegradable components in drug delivery systems. 

G. C. Ceschel, R. Badiello, C. Ronchi, and P. Maffei, Degradation of components in drug formulations A comparison between HPLC and DSC methods, J. Pharm. Biochem. Anal. 32 (2003), 1067-1072. 

Other drugs studied by Moore et al. include chlorine containing photosensitizers (178), the effect of surfactants on photosensitizers (179), photosensitization by malarial drugs (180), nalidic and oxolinic acids (181), 6-mercaptopurine (182), azathioprine and nitroimidazole (183), 7-methylbenz[c]acridine and related products (184), naproxen, ben-oxaprofen and indomethacin (185), mefloquine (186), sulfamethoxazole and trimethoprim (187), benzydamine (188), photodecomposition of hydrochlorthiazide (189), tetracycline (190), frusemide (191), 6-mercaptopurine (192), 7-methylbenz[c]acridine (193), metronidazole, misonidazole and azathioprine (194), misonidazole and metronidazole (195), benzydamine (196), components in drug formulations (197) and sulfamethoxazole (198,199). 

Tonnesen HH. Photochemical degradation of components in drug formulations. I. An approach to the standardization of degradation studies. Die Pharmazie 1991 46 263. 

The much lower concentrations of compounds In food compared with those of active components In drugs. 

Components in drug mixtures may be simply identified by dissolving the sample in 2 ml of ethanol, filtering, evaporating the filtrate to 0.5 ml, and applying 5 tl portions to a silica gel-gypsum layer for development with ethyl acetate-ethanol-aq. 25% NH3 (18 2 1 v/v). Iodine vapor is used to detect phenobarbitone, bromvaletone, papaverine hydrochloride, and caffeine. 

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