Commiphora molmol

Myrrh (Commiphora molmol). Reprinted from Culbreth DMR. (1927). Materia Medica and Pharmacognosy, 7th ed. Philadelphia Lea Febiger. 

N.A. Commiphora molmol Engl, ex Tschirch. C. myrrha Engler Gum, acidic polysaccharides, resin.99 Antiseptic, astringent, expectorant, anti-inflammatory, antispasmodism, carminative. 

Mjrrh is an oleo gum resin obtained from the stem of Commiphora molmol, a tree that grows in north-east Africa and the Arabian Peninsula. In mice, myrrh showed no mutagenic effects and was a potent cytotoxic drug against solid tumor cells (5). The antitumor potential of C. molmol was comparable to that of cyclophosphamide. Studies in hamsters suggested an antischistosomal activity of myrrh (6). 

Massoud A, El Sisi S, Salama O, Massoud A. Preliminary study of therapeutic efficacy of a new fasciolicidal drug derived from Commiphora molmol (myrrh). Am J Trop Med Hyg 2001 65(2) 96-9. 

With these two products available, we undertook the synthesis of (+)-1,2-dihydrotubipofhrane 431 [61], and also attempted the synthesis of the reported structure for the enantiomeric form of tubipofurane (436) and the reported structure for furanoeudesma-1,3-diene (441) [62]. Tubipofurane is a furanoeudesmane isolated from the stolonifer Tubipora musica, and it shows ichtiotoxicity against Orizias latipes. The 8-acetoxy derivative of tubipofurane is active against B-16 melanoma cells in vitro. Furanoeudesma-1,3-diene, on the other hand, has been isolated from Commiphora molmol and has been shown to have analgesic properties [63]. Transformation of compound 425 into 431 involved reduction of the... 

Sesquiterpenes are significant constituents of myrrh resin Commiphora molmol). Recent stndies indicate that sesqniterpenes are responsible for local anaesthetic, antibacterial and antifungal properties (Dolara et al. 2000). 

Oleo-gum-resin exudes from incisions made in bark of myrrh trees (family Burseraceae) in North Africa and the Arabian Peninsula— Commiphora molmol—and India—C. mukul— where it is known as guggul. The main constituents are resin 25-40%, gum 60%, volatile oil 2.5-8% along with a bitter principle. Its actions are antiseptic, antimicrobial, astringent and stimulant. 

Myrrh Resin Commiphora molmol Middle East... 

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