Tubipora musica

With these two products available, we undertook the synthesis of (+)-1,2-dihydrotubipofhrane 431 [61], and also attempted the synthesis of the reported structure for the enantiomeric form of tubipofurane (436) and the reported structure for furanoeudesma-1,3-diene (441) [62]. Tubipofurane is a furanoeudesmane isolated from the stolonifer Tubipora musica, and it shows ichtiotoxicity against Orizias latipes. The 8-acetoxy derivative of tubipofurane is active against B-16 melanoma cells in vitro. Furanoeudesma-1,3-diene, on the other hand, has been isolated from Commiphora molmol and has been shown to have analgesic properties [63]. Transformation of compound 425 into 431 involved reduction of the... 

Iguchi, K., Mori, K., Suzuki, M., Takahashi, H., and Yamada, Y. (1986b) Marine fiuano-sesquiterpenoids tubipofiiran and 15-acetoxytubi-pofuran from stolonifer Tubipora musica linneaus. Chem. Lett., 1789-1792. 

There are few representatives of elemane and nor-elemnane carbon skeletons, but there are many examples of its diterpenic isoprenolog, known imder the name lobane (see below). The carbon skeletons of eudesmane and selinane differ only in the stereochemistry of the jimction between the two cyclohexanes. Currently, derivatives of eudesmane seem characteristic of Alcyonacea, and those of sebnane characteristic of Stolonifera, although for the latter the published results relate only to the spedes Tubipora musica (blue coral). 

---