Orizia latipes

Cantrell, S.M., L. Lutz, D.E. Tillitt and M. Hannink. Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) the embryonic vasculature is a physiological target for TCDD-induced DNA damage and apoptotic cell death in medaka (Orizias latipes). Toxicol. Appl. Pharmacol. 141 23-34, 1996. 

With these two products available, we undertook the synthesis of (+)-1,2-dihydrotubipofhrane 431 [61], and also attempted the synthesis of the reported structure for the enantiomeric form of tubipofurane (436) and the reported structure for furanoeudesma-1,3-diene (441) [62]. Tubipofurane is a furanoeudesmane isolated from the stolonifer Tubipora musica, and it shows ichtiotoxicity against Orizias latipes. The 8-acetoxy derivative of tubipofurane is active against B-16 melanoma cells in vitro. Furanoeudesma-1,3-diene, on the other hand, has been isolated from Commiphora molmol and has been shown to have analgesic properties [63]. Transformation of compound 425 into 431 involved reduction of the... 

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