Diversity and Library Design

Typically in drug design there are four possible scenarios for the amount of information we are starting with  

We do not know the. structure of the receptor, but we do have known ligands or inhibitors. This was once the most comituiit 

TABLE 3-2 Similarity of Structures to Oiethylstllbestrol (DES), Using Various Descriptors 

Polar No. of No. of No. of 2D Molecular Surface H-Bond H-Bond Rotatable Similarity Log P Area Acceptors Donors Bonds to DES 

The methods of selecting structure.s come mainly from stati.slics and QSAR. They include the following  

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