Small molecular weight compounds

Nasal Administration. The nasal mucosa is relative permeable to small molecular weight compounds. The most notorious example is cocaine. Cocaine that is snorted is both rapidly and extensively absorbed. Small peptides have also been successfully administered nasally, although the bioavailability is low. However, where the availability is not critical, nasal administration of peptides has been successful. The best example is... 

Yazdanian, M. Glynn, S. L. Wright, J. L. Hawi, A., Correlating partitioning and Caco-2 cell permeability of stucturally diverse small molecular weight compounds, Pharm. Res. 15, 1490-1494 (1998). 

MATHEY Phosphorus-Carbon Heterocyclic Chemistry The Rise of a New Domain McKILLOP Advanced Problems in Organic Reaction Mechanisms OBRECHT Solid Supported Combinatorial and Parallel Synthesis of Small-Molecular-Weight Compound Libraries... 

Allosteric regulatory molecules are small molecular weight compounds which may be coenzymes (NAD+, ATP, etc.) or intermediate substrates, possibly generated by enzymes found within the same pathway as the regulated enzyme. Alternatively, the allosteric modulator may be generated within another, perhaps complementary, pathway. For example, a regulator may be stimulatory for a catabolic route and at the same time inhibitory for the opposing anabolic pathway. 

Most sweet compounds including the commercial sweeteners, are small molecular weight compounds but there are also sweet macromolecules both synthetic and natural. It was thought that compounds with molecular masses over 2 500 would generally be tasteless. It was assumed that macromolecules such as proteins could elicit a sweet taste similar to small molecules such as sucrose and stevioside until the discovery of miraculin. 

E Small molecular weight compounds of diverse structures p-Nitrophenol Disulfiram Ethanol Many haloalkenes and haloalkanes nitrosamines, benzenes... 

OBRECHT Solid Supported Combinatorial Parallel Synthesis of Small Molecular-Weight Compound Libraries... 

Fig. 3 Hydrolyzable, acid-sensitive and reducible bonds. Efficient and biocompatible high molecular weight polymers are created by reversible linkage of small molecular weight compounds. Thus, programmed biodegradation due to, for example, hydrolyzable ester bonds [92] (a), acid-sensitive ketal (b) or acetal linkages (c) [98] is possible. The reducing cytosolic environment can also be taken advantage of in order to create biodegradable polymers by introduction of disulfide bonds as shown in (d) [105, 106]...

Testing the Permeability (Sensitivity) of Yeast Strains SKY54 and SKY197 With Targeted Antifungals, and to a Diverse Chemical Library of Small-Molecular-Weight Compounds... 

Neuroprotection and Enhancement of Neurite Outgrowth With Small Molecular Weight Compounds From Screens of Chemical Libraries Donard S. Dwyer and Addie Dickson... 

The flame ionization detector has a very wide dynamic range, has a high sensitivity and, with the exception of about half a dozen small molecular weight compounds, will detect all substances that contain carbon. It is, without doubt, the most useful GC detector available and by far that most commonly used in GC analyses. 

---