Combinatorial chemical libraries activity range

Amines, carboxylic acids, and isonitriles. A wide range of primary/ secondary amines (95,398), carboxylic acids (2,158), and isonitriles (644) are commercially available from the Available Chemical Directory (ACD) as of September 2007 (Table 1). The compounds used for the Ugi reaction on the aldehyde activated agarose vary from case to case they must be dissolved in an appropriate buffer, either an aqueous solution or an organic solvent such as methanol. Table 2 presents the list of the different amines (A1-A8), carboxylic acids (C1-C6), and isonitrile (II) components used for the Ugi combinatorial library prepared in this work (see Note 4). 

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