Colonic targeting microflora

It was for these reasons that we engaged in a colon-targeted systems design project that was based on a more effective and predictable gradient like microflora differences between small and large intestine to eventually replace simple time-or pH-triggered systems. 

In general, probiotic bacteria do not colonize the human intestinal tract permanently, but specific strains are able to transiently colonize or persist for some time in the intestine and may modulate the indigenous microflora. The rationale for modulating the gut microflora by means of probiotics derives from the demonstration that this microflora is important to the health of the host. Specific probiotics have been shown to colonize temporarily the human intestinal tract, thereby modulating the intestinal microflora both locally and at the commensal level. Such modification has not been reported to be permanent rather it is related to a balancing of aberrant or disturbed microflora to assist it to return to normal metabolic and physiological activities. Such modulation and restoration of the normal state of the microflora activity is a key target for probiotic action. However, the state of the microflora should be well characterized to enable the selection of specific probiotics to counteract the aberration or disturbance in question. 

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