Collagen, vii

Collagen VII forms the anchoring fibrils in the reticular lamina that link the basement membrane to underlying connective tissue (Burgeson et al., 1985 Sakai et al., 1986). These attachment fibers are particularly abundant along the epidermal-dermal basement membrane, in the amnion, in lung, and in other sites where basement membranes are under tension. The fibers of collagen VII form a centrosymmetrically banded structure... 

Wakelin SH, Allen J, Zhou S, Wojnarowska F. Drug-induced linear IgA disease with antibodies to collagen VII. Br J Dermatol 1998 138(2) 310-14. 

Timpl R, Wolff I, Wick G, Furthmayr H, Steffen C (1968) Immunogenicity and specificity of collagen. VII. Differences between various collagens demonstrated by cross-reactivity studies. J Immunol 101 725-729... 

Craven NM,Watson RE,Jones CJ, Shuttleworth CA, Kielty CM, Griffiths CE. Clinical features of pho-todamaged human skin are associated with a reduction in collagen VII. Br J Dermatol 1997 137 344-50. 

Different tissues in the body have different types of collagen (there are 27 in total) classified as collagen types I, II, and so on. Type I collagen, for example, the most abundant collagen of the human body, makes up the tendons and the organic part of bone type II collagen makes up articular cartilage type IV makes up the eye lens type VII and type XI colla-... 

The columnar, cuboidal basal cells are 18-20 xm in height and 8-10 iim in diameter. They form a monolayer adhered to a basement membrane by hemidesmosomes which are linked to anchoring fibrils of collagen type VII. At the lateral borders, basal cells are extensively interdigitated and joined together in places only by junctional complexes (zonula adherens), desmosomes, and gap junctions. 

Another 3-D cornea model, comprising rabbit primary cultures of epithelial and stromal cells as well as mouse immortalized endothelial cells, was described in 1994 by Zieske and coworkers [70], They showed the influence of endothelial cells on the formation of a tightly packed, multilayered epithelium as well as the expression of laminin, type VII collagen, a6 integrin, keratin K3, and a-enolase. Furthermore, their findings suggested that the formation of an in vivo-like epithelium requires the cultivation of the 3-D corneal construct under AIC conditions. By contrast, LCC methods of cultivating corneal equivalents in the absence of endothelial cells failed to promote the expression of differentiation markers and basement membrane components. 

Beaded filament and anchoring fibril collagens (types VI and VII) 508... 

The NCI domain of type VII collagen binds to the /33 chain of laminin, " laminin-5 a3(33 2), and type IV collagen. The triple helical domain of type VII collagen functions to promote the migration of human keratinocytes. °... 

Mutations of COL7A1 cause a skin disease called dystrophic epidermolysis bullosa. It is a blistering disease caused by the separation of the dermal-epidermal junction. Biochemical analysis revealed the single amino acid substitution in type Vll collagen that affects the supramolecular assembly of type VII... 

Type VII collagen is composed of three identical a chains, each consisting of a 145 kDa central collagenous triple helical segment, flanked by a large 145 kDa N-terminal NC domain (NCI) and a smaller 34 kDa... 

R. E. Burgeson, Type VII Collagen. In Structure and Function of Collagen Types R. Mayne, R. E. Burgeson, Eds. Academic Press Orlando, FL, 1987 pp 145-172. 

Human fibroblast Collagenase (HFC) 57.000 (glycosylated) 52.000 0.32 Type 1, II, III, VII and X collagens gelatins a-Ms casein fibroblasts keratinocytes macrophages U937 cells endothelial cells [27,34]... 

Network-forming collagens Types IV and VII form a three-dimensional mesh, rather than distinct fibrils (Figure 4.4). For example, type IV molecules assemble into a sheet or meshwork that constitutes a major part of basement membranes. [Note Basement membranes are thin, sheet-like structures that provide mechanical support for adjacent cells, and function as a semipermeable filtration barrier for macromolecules in organs such as the kidney and the lung.]... 

Type I, II, and III collagens are fibrillar, and are found in tendon, skin, bone, cornea, carti lage, vitreous body, and blood vessels. Types IX and XII are fibril-associated, and are found in cartilage, tendon, and ligaments. Type IV and VII form networks in basement membrane and beneath stratified squamous epithelia. 

II, III, IV, and VII collagens. Other defects involve lysyl hydroxylase and procollagen N-proteinase.a-d... 

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