COILS program

The success of the COIL program generated interest in the possibilities for creating analogous chemically driven laser systems. It was quickly recognized that the metastable a A states of NF and NCI may be suitable energy carriers for lasers. These molecules are isovalent with O2, and have... 

P. N. Haubenreich, W. C. Anderson, J. N. Luton, and P. B. Thompson, Plan for the Large Coil Program, ORNL/TM-5824, Oak Ridge National Laboratory, Oak Ridge, Tennessee (1977). 

The Pascal code was updated to handle four channels. To follow the inspection speed all raw measuring data were captured and stored in the computer. All data for one coil could be stored in the computer memory (RAM) and transferred to the disk before inspection of the next coil. Evaluation of the data could be performed on-line or later using a special evaluation program. 

Intermittent conductivity measurement controlled, with the electrode placed in the BD line before the BD valve. In this arrangement the controller program opens the BD valve for a timed period (= 1 minute), sufficient for fresh BW to flow past the electrode and an accurate electrical conductivity measurement to be taken. The BD valve remains open until the conductivity falls below a set point. Again, this arrangement is improved with the use of a cooling coil. It is the most widely employed intermittent BD arrangement for FT boilers. 

Possible secondary structures of pardaxin (6) were predicted by the Delphi program (12) using decision constants (DHA = -75, DHE = 50) that favor a helices over extended segments and by the Amphi program that identified possible amphipathic a helices and p strands (Guy, unpublish data). Delphi predicted that pardaxin segments 1-8 and 16-25 were a helices and the remainder may be coils or turns. Amphi predicted that segments 1-12 and 13-28 could form amphipathic a helices. 

Pyrolysis-Gas Chromatography-Mass Spectrometry. In the experiments, about 2 mg of sample was pyrolyzed at 900°C in flowing helium using a Chemical Data System (CDS) Platinum Coil Pyrolysis Probe controlled by a CDS Model 122 Pyroprobe in normal mode. Products were separated on a 12 meter fused capillary column with a cross-linked poly (dimethylsilicone) stationary phase. The GC column was temperature programmed from -50 to 300°C. Individual compounds were identified with a Hewlett Packard (HP) Model 5995C low resolution quadruple GC/MS System. Data acquisition and reduction were performed on the HP 100 E-series computer running revision E RTE-6/VM software. 

Bilgicer, B. Xing, X. Kumar, K. Programmed self-sorting of coiled coils with leucine and hexafluoroleucine cores. J. Am. Chem. Soc. 2001, 123, 11815-11816. 

Inside the column oven, the solvent flows through 0.75 m of 0.009 in. I.D. conditioning coil, through a low dead-volume tee containing a thermocouple to monitor solvent temperature, and then to the column. The column oven, with a 425 0 maximum temperature, is heated by two 2-kilowatt wire wound heaters which are controlled with a Gulton Model 2GB Controller which provides either Isothermal or programmed temperature control. 

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