Cohn

First I would like to ask you about your family background. 

My parents were immigrants from Russia. My father was studying to be a rabbi, but he decided not to be ordained and he became a militant atheist. His family was rather wealthy in Russia and he was the only member of his family who came to this country when he was 21 years old. My mother, on the other hand, came with her family to America when she was 17 years old. It was soon after the unsuccessful Russian revolution of 1905. I never found out exactly why they left Russia, because they never talked about it, but I know there were pogroms against the Jews in Russia at that time. They were middle class, but their financial situation was deteriorating. One of my aunts was very angry with my grandmother because under financial stress, she kept the maid, but sold the cow, and there was no milk for her. My parents had known each other in Europe, but got married in America, and I was born in New York City. 

Which part of Russia did your parents come from  

It was Russia when they left, then it became Poland, then it was Russia again, and today it is Belarus. They spoke Russian rather than Polish, in addition to Yiddish. I learned Yiddish as a child and I was bilingual. My father was very interested in Yiddish culture, he was a Yiddishist. From the time I was 13 to 19, we lived in a cooperative that was dedicated to preserving Yiddish Kultur. 

When I was in high school, we had a very good chemistry teacher. We had two years of chemistry instead of the customary one year in most high schools. My best friend s father owned a couple of beauty salons and manufactured cosmetics. He told both of us that cosmetic chemistry was a great opportunity for women. By the time I went to college, it was Hunter College, I was convinced that I wanted to study chemistry. 

Silver salts which do not explode when heated 

Pyridine and quinoline derivatives and amino-acids frequently give chnnictcristic copper and nickel saltsy 

IS dissolved, must either be free from acids or must previously be exactly neutralized by means of N/io alkali. 

Certain lactones can be titrated with alkali although they are insoluble in sodium hydrogen carbonate. ot-Dibenzoylsuccinic lactone may be easily titrated, in 

In very many cases carboxylic and phenolic hydrogen may be differentiated by the esterification of the com- 

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Chatfield C and A J CoHns 1980. Introduction to Multivariate Analysis. London, Chapman Hall. Desiraju G R 1997. Crystal Gazing Structure Prediction and Polymorphism. Sdence 278 404-405. Everitt B.S. 1993 Cluster Analysis. Chichester, John Wiley Sons. 

Factor VIII, immunoglobulin, and albumin are all held as protein precipitates, the first as cryoprecipitate and the others as the Cohn fractions FI + II + III (or FII + III) and FIV + V (or FV), respectively (Table 7, Fig. 2). Similarly, Fractions FIVj + FIV can provide an intermediate product for the preparation of antithrombin III and a-1-proteinase inhibitor. This abiUty to reduce plasma to a number of compact, stable, intermediate products, together with the bacteriacidal properties of cold-ethanol, are the principal reasons these methods are stiU used industrially. 

Alpha-1-proteinase inhibitor and antithrombin III are used to treat people with hereditary deficiencies of these proteins. Both can be recovered from Cohn Fraction IV (Table 7) using ion-exchange chromatography (52) and affinity chromatography (197), respectively. Some manufacturers recover antithrombin III directiy from the plasma stream by affinity adsorption (56,198,199). 

E. J. Cohn, ia Papers on the Separation of the Formed Elements of Plasma, Laboratory of Physical Chemistry, Harvard University, Boston, 1950. 

Cohn and EdsaH, Proteins, MminoMcids, andPeptides, ACS Monograph Series No. 90, Reiuhold Publishing Co., New York, 1943. 

O. Meth-Cohn, Org. Chem. Sulphur Selenium Tellurium., 4, 828 (1979). 

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