Inversion, cognitive

Manichean Dualism and Cognitive Inversion The teleological orientation of the positivist-Whig historiography is immediately evident in the idea of the Chemical Revolution as the origins of modern chemistry, as the originary moment in the exfoliation of the facts, theories and methods to be found in modern textbooks of chemistry. Thus James R. Partington claimed in 1937 that Lavoisier s Traite read like a rather old edition of a... 

Bonithon-Kopp et al. (1986b) investigated another potential marker for lead exposure. Maternal and infant hair lead levels, determined from hair samples taken at birth, were found to be correlated inversely with results on neurobehavioral tests (McCarthy Scales of Children s Abilities) when the children were tested at 6 years of age. Other studies have also reported associations between hair lead levels and behavioral or cognitive test scores, but measures of lead in hair may not accurately reflect internal body burden of lead, and such data should not be used to evaluate internal dose-response relationships (EPA 1986a). 

Chambers MS, attack JR, Broughton HB, CoUinson N, Cook S, Dawson GR, Hobbs SC, Marshall G, Maubach KA, PiUai GV, Reeve AJ, MacLeod AM (2003) Identification of a novel, selective GABAa 5 receptor inverse agonist which enhances cognition. J Med Chem 46 2227-2240... 

Medical illness or medication side effects may directly affect cognition virtually all classes of medication have been implicated. In adult patients, glucocorticoids can impair memory at relatively low doses (Keenan et ah, 1995 Newcomer et ah, 1999), as there are postulated effects on hippocampal neurons. Newcomer et ah, (1999) have reviewed the literature on illnesses in adults in which memory inversely correlates with cortisol levels, such as in Cushing s disease, Alzheimer s dementia, schizophrenia, and depression. There is no similar literature on the pediatric population. The risk of memory impairment puts chronic steroid treatment, such as that seen in certain pediatric rheumatologic disorders and severe asthmatics, for example, into a different perspective, however. Documentation of memory both before and during chronic steroid treatment might help determine detrimental effects in the pediatric population. 

Hot and cold explanations correspond to causal interest-explanations and to position explanations respectively. The central example in Marx involves the "material interest and social position" of classes, further discussed in 8.2.2 and 8.2.3. A somewhat more broadly based type of position-explanation is discussed in d.2.4. The mechanisms cited in 8.2.1 - the inversion of subject and predicate, of creator and created - are partly cognitive, partly motivational in character. The cases surveyed in 8.3 offer position-explanations as well as functional interest-explanations, the be t-lcnown and least well-founded of Marx s theories of ideology. TypicaHy, they amount to explanations of the beliefs and values obtaining in-a society in terms of their beneficial consequences for the ruling class. Sometimes they work in... 

Merck researchers have recently disclosed a series of 3-phenyltriazolopyridazines with excellent selectivity for the a,-containing GABA isoform (186) (Table 14.5). Selectivity for the a, subunit was maintained within the series when the A-ring was saturated or had alternative ring fusion. The inverse agonist L-792782 (47) was selected from this series and evaluated for cognition enhancement, discussed below. 

---