Merck research

At Merck Research Laboratories, the imidazole ring ia losartan (81, K = n — butyl), a novel clinical candidate against hypertension, was replaced with a pyrazole ring (52). Some of the best compounds are represented by formula (82), where K = n — butyl and R = 2,6-dichlorophenyl, 2-chlorophenyl, or... 

IRBM - Merck Research Laboratories, Pomezia, Italy... 

Process Research Department, Merck Research Laboratories, P. O. Box 2000, Rahway, NJ... 

Chemical Research and Development, Pfizer Global Research and Development, Groton Laboratories, Groton, CT 06340, USA. Jerry Murry is currenty located at Process Research Department, Merck Research Laboratories, Merck and Co. Inc., Rahway, NJ, 07065. 

Include a 3D ligand-based method. In our internal efforts across two companies, we arrived at the same conclusion as the Merck researchers [106] that a 3D similarity method appears to offer a good balance between effort expended and the number and novelty of hits generated. 

There are a few key enzymes for the proliferation of human immunodeficiency virus (HIV). Reverse transcriptase is one of them since HIV is a member of the DNA viruses. Efavirenz (1) is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) and was discovered at Merck Research Laboratories [1] for treatment of HIV infections. Efavirenz was originally licensed to DuPont Merck Pharmaceuticals which was later acquired by Bristol-Myers Squibb.11 The typical adult dose is 600 mg once a day and 1 is one of three key ingredients of the once-a-day oral HIV drug, Atripla (Figure 1.1). 

Merck Research Laboratories Process Research 770 Sumneytown Pike P.O. Box 4... 

Paul S. Anderson, Ph.D. Vice President of Chemistry Merck Research Laboratories (retired)... 

Present address Merck Research Laboratories, Rahway, NJ 07065, USA... 

Mandana Asgharnejad, Ph.D. Research Fellow, Merck Research Laboratories, West Point, Pennsylvania... 

Merck Research Laboratories, West Point, Pennsylvania... 

Editor Andy Stamford Merck Research Laboratories Kenilworth New Jersey... 

The biomimetic approach to the core skeleton of C-nor-D-homosteroid was first developed by the Merck research group (Scheme 2.1) [16]. In the Merck procedure,... 

The discovery of oxazoline hydroxamates as potential inhibitors of LpxC was the result of high-throughput screening of large libraries of compounds at the Merck Research Laboratories in collaboration with the Department of Biochemistry, Duke University Medical Center [95]. The lead compound, L-573,655, was a racemic mixture of 4-carbohydroxamido-2-phenyl-2-oxazoline, which had been previously made by Stammer et al. [96] as a precursor in the chemical synthesis of cyclosporine. Namely, (R,S)-serine methyl ester hydrochloride (149) is converted into (R,S)-4-carbomethoxy-2-phenyl-2-oxazoline (150) via treatment with ethyl benzimidate using the Elliot procedure [97]. Treatment of this ester with one equivalent each of hydroxylamine and sodium methoxide in methanol at room temperature affords the desired (R,S)-4-carbohydroxamido-2-phenyl-2-oxazoline (151), as depicted in Scheme 30. 

This chapter is dedicated to Dr. James T. Stewart on the occasion of his 70th birthday. Formerly a professor at the University of Georgia s College of Pharmacy and my PhD advisor, Dr. Stewart is now retired. My thanks also to Dr. Wu Du of the Merck Research Laboratories and Dr. Mark Arnold of BMS for their reviews and comments. 

Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA Department of Metabolic Disorders, Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA... 

The first practical and efficient asymmetric alkylation by use of chiral phase-transfer catalysts was the alkylation of the phenylindanone 15 (R1=Ph), reported by the Merck research group in 1984.114-161 By use of the quaternary ammonium salt 7 (R=4-CF3i X=Br) derived from cinchonine, the alkylated products 16 were obtained in excellent yield with high enantiomeric excess, as shown in... 

Budavari Se. The Merck Index (12th ed). Whitehouse Station Merck Research Laboratories 1996. 

Merck Research Laboratories Merck Research Laboratories... 

Institut de Qmmica Computational and Departament de Quimica, Universitat de Girona, E-17071 Girona, Catalonia, Spain . 2 Medicinal Chemistry Dept., Merck Research Laboratories, Merck Co., West Point PA. 

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