Coefficient measurement

Scattering Coefficient measure of the ability of particles to scatter light measured in number proportional to the "amount" of light scattered per unit distance. 

A detailed method of determining pressure coefficients is to perform experiments with a wind tunnel facility. Cochran and Cermak compared wind tunnel pressure coefficient measurements with field measures on a test building and found excellent results, with the exception of small areas beneath the vortices near the upwind roof corner for winds approaching at 45 . For infiltration and natural ventilation designs, wind tunnel results should be sufficiently accurate. 

Absorption coefficient Measure of the amount of sound or heat absorption provided by a material. 

Figure 1. Thermal-expansion coefficients measured on cooling (300-77K and 4.2-2K) and heating (4.2-77K) along (OOl)e directions for In-26.5 at%Tl in the temperature range 2-3 OOK, with different external stress fields applied. (From reference 7)...

Mass absorption coefficient, measurement for interelement corrections, 174... 

Ribosomes are ancient ribonucleoprotein complexes that are the sites of protein synthesis in living cells. Their core structures and fundamental functional mechanisms have been conserved throughout the three domains of life bacteria, archaea and eukaryotes. All ribosomes are organized into two subunits that are defined by their apparent sedimentation coefficient, measured in Svedberg units (S). There is a general... 

C. Relative Extinction-Coefficient Measurements for Naked Silver... 

FIGURE 26.31 Braking coefficient measured on a wet test track with the Mobile Traction Laboratory (MTL) as function of slip. 

Balcom, B Fischer, A Carpenter, T Hall, L, Diffusion in Aqueous Gels. Mutual Diffusion Coefficients Measured by One-Dimensional Nuclear Magnetic Resonance Imaging, Journal of the American Chemical Society 115, 3300, 1993. 

Comparison of crystal growth rate coefficients measured in ISC and FBC... 

Octanol" and "Membrane" pK in Partition Coefficients Measurement 67 Tab. 3.1 Octanol-water and liposome-water partition coefficients. ... 

A detailed descriphon of octanol-water distribuhon coefficient measurements by shake-flask can be found in publications by Dearden [2] and Hansch [24], The method usually involves the following solubilization of the compound in a mixture of mutually presaturated buffered water and octanol, agitation unhl equilibrium has been reached, careful separation of octanol and aqueous phases, and direct measurement of the solute concentration in both phases. Although seemingly simple, the method has a number of caveats making it inappropriate for some compounds. 

However, as stated above, the partition coefficients measured by the shake-flask method or by potenhometric titration can be influenced by the potenhal difference between the two phases, and are therefore apparent values which depend on the experimental condihons (phase volume ratio, nature and concentrahons of all ions in the solutions). In particular, it has been shown that the difference between the apparent and the standard log Pi depends on the phase volume raho and that this relationship itself depends on the lipophilicity of the ion [80]. In theory, the most relevant case for in vivo extrapolation is when V /V 1 as it corresponds to the phase ratio encountered by a drug as it distributes within the body. The measurement of apparent log Pi values does not allow to differentiate between ion-pairing effect and partihoning of the ions due to the Galvani potential difference, and it has been shown that the apparent lipophilicity of a number of quaternary ion drugs is not due to ion-pair partitioning as inihally thought [80]. 

Since it was proposed in the early 1980s [6, 7], spin-relaxation has been extensively used to determine the surface-to-volume ratio of porous materials [8-10]. Pore structure has been probed by the effect on the diffusion coefficient [11, 12] and the diffusion propagator [13,14], Self-diffusion coefficient measurements as a function of diffusion time provide surface-to-volume ratio information for the early times, and tortuosity for the long times. Recent techniques of two-dimensional NMR of relaxation and diffusion [15-21] have proven particularly interesting for several applications. The development of portable NMR sensors (e.g., NMR logging devices [22] and NMR-MOUSE [23]) and novel concepts for ex situ NMR [24, 25] demonstrate the potential to extend the NMR technology to a broad application of field material testing. 

Pore shape is a characteristic of pore geometry, which is important for fluid flow and especially multi-phase flow. It can be studied by analyzing three-dimensional images of the pore space [2, 3]. Also, long time diffusion coefficient measurements on rocks have been used to argue that the shapes of pores in many rocks are sheetlike and tube-like [16]. It has been shown in a recent study [57] that a combination of DDIF, mercury intrusion porosimetry and a simple analysis of two-dimensional thin-section images provides a characterization of pore shape (described below) from just the geometric properties. 

Geary RS, Wall CM, Miller MA, et al. 1994. Partition coefficient measurements of diisopropyl methylphosphonate (DIMP) and trichloroethylene in rats using microdialysis and incorporated in physiologically-based pharmacokinetic (PBPK) modelling [Abstract], Society of Toxicology 33rd Annual Meeting, Dallas, TX 13-17 March, 1994. Paper No. 82. 

A method where phospholipids are entrapped in the pores of resin beads, in the forms of multilamellar vesicles, has been described [313-319,376]. In some ways, the idea is similar to that of IAM chromatography, even though the resin is modified differently. The retention indices correlate very well with the partition coefficients measured in liposome-water systems (described below). 

Olive oil was the original model lipid for partition studies, and was used by Overton in his pioneering research [518,524], It fell out of favor since the 1960s, over concerns about standardizing olive oil from different sources. At that time, octanol replaced olive oil as the standard for partition coefficient measurements. However, from time to time, literature articles on the use of olive oil appear. For example, Poulin et al. [264] were able to demonstrate that partition coefficients based on olive oil-water better predict the in vivo adipose-tissue distribution of drugs, compared to those from octanol-water. The correlation between in vivo log Kp (adipose tissue-plasma) and log (olive oil-water) was 0.98 (r2), compared to 0.11 (r2) in the case of octanol. Adipose tissue is white fat, composed mostly of triglycerides. The improved predictive performance of olive oil may be due to its triglyceride content. 

Fig. 2.14 The scheme of the cylindrical lens method for diffusion coefficient measurement (1) the source with the horizontal slit (2) the condenser supplying a handle of parallel beams (3) the cuvette with a refraction index gradient where the beams are deflected (4) the objective lens focusing the parallel beams to a single point (5) the optical member with an oblique slit and a cylindrical lens (6) the photosensitive material...

The authors would like to acknowledge the contributions of the following researchers J.R. DeBaun and L.S. Mullen-Rokita, for helpful discussions E.B. Cramer, for assisting with the adsorption measurements L.-S. Yu-Farina, for the water solubility and partition coefficient measurements H. Myers, for the vapor pressure measurements and R.R. Winter, for running the MACCS molecular structure analyses. 

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