Adipose tissue distribution

Olive oil was the original model lipid for partition studies, and was used by Overton in his pioneering research [518,524], It fell out of favor since the 1960s, over concerns about standardizing olive oil from different sources. At that time, octanol replaced olive oil as the standard for partition coefficient measurements. However, from time to time, literature articles on the use of olive oil appear. For example, Poulin et al. [264] were able to demonstrate that partition coefficients based on olive oil-water better predict the in vivo adipose-tissue distribution of drugs, compared to those from octanol-water. The correlation between in vivo log Kp (adipose tissue-plasma) and log (olive oil-water) was 0.98 (r2), compared to 0.11 (r2) in the case of octanol. Adipose tissue is white fat, composed mostly of triglycerides. The improved predictive performance of olive oil may be due to its triglyceride content. 

Liver and adipose tissue are the major storage compartments for CACs. Ratios between liver and adipose tissue distribution are species dependent and follow the order rodents > birds > humans > fish.30 In marine mammals this ratio is determined by their relatively large adipose tissue compartment, with large storage capacities. CAC metabolites may bind to specific target proteins, e.g. in blood, kidney or lung. 

Kekes-Szabo, T, Hunter, G. R., Nyikos, I., Williams, M., Blaudeau, T., and Snyder, S. (1996), Anthropometric equations for estimating abdominal adipose tissue distribution in women, fnt. J- OhesiYy 20, 753-758. 

Bjomtorp, P. (1991). Adipose tissue distribution and function. M. /. Obesity 15,67-81. 

Bjomfoip, R (1996). The regulation of adipose tissue distribution in humans. Int.. Obesity 20,291-302. 

Goodpaster BH, Thaete FL, Kelley BE. Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. Am J Clin Nutr 2000 71 885-892. 

Katzmarzyk PT, Perusse L, Rao DC, Bouchard C. Familial risk of obesity and central adipose tissue distribution in the general Canadian population. Am. J. Epidemiol. 1999 149 933-942. 

CDG-Ia patients (some 300 known worldwide) show mild to severe neurological disease and variable involvement of many organs. Dysmorphy ranges from mild and aspecific to a characteristic abnormal subcutaneous adipose tissue distribution with fat pads and nipple retraction. Mortality is about 20% in the first years of life [3-5]. 

The waist—hip ratio provides a convenient way of defining two patterns of adipose tissue distribution ... 

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