Cocaine addition about

The situation of daily dependent heroin use was sufficient to merit methadone treatment, but a (requested) detoxification attempt was not successful. His initial dosage was reinstated and the urine tests at his further appointments did not show heroin, but four consecutive tests showed cocaine, benzodiazepines and cannabis, in addition to his methadone. He was generally unenthusiastic about methadone, and after a pattern of missing an increasing number of collection days he dropped out of engagement with us. 

Local anesthetics block the sodium channels, are cardiac depressants, and bring about a ventricular conduction defect and block that may progress to cardiac and ventilatory arrest if toxic doses are given. In addition, these agents produce arteriolar dilation. Circulatory failure may be treated with vasopressors such as ephedrine, metaraminol (Aramine), or mephentermine (Wyamine). Artificial respiration and cardiac massage may also become necessary. Among the local anesthetics, only cocaine blocks the uptake of norepinephrine, causes vasoconstriction, and may precipitate cardiac arrhythmias. 

In addition, the purveyors of thousands of patent medicines—containing drugs such as opium, morphine, heroin, and cocaine—sold them without restriction. The makers of these medicines, who regularly made false claims about their therapeutic value, did not even list ingredients or warnings on the labels. 

The use of dilute aqueous solutions of HC1 [142, 152, 153] or phosphate buffer (pH 6.5-5) [133] are very appropriate for the extraction of amphetamines and other compounds in basic character. In this case, the extraction times are about 20 h. When supported by increased temperature, the extraction lasts only for 2 h, but it is not effective for the extraction of lipophilic compounds such as THC. The use of aqueous solutions of HC1 causes partial or complete hydrolysis of some substances, so phosphate buffer at pH 5 is preferred for the determination of cocaine and 6-MAM in these conditions these two molecules appear to have increased stability [154], In addition to acidic aqueous solutions, formic acid instead of hydrochloric acid solutions are also used in organic solvents [136],... 

Cocaine is found in higher concentrations in hair samples than its metabolite benzoylecgonine, generally in a ratio of about 3 to 1. Contamination should always be considered the consumption can additionally be proved by the detection of cocaethylene. 

Melting point not below 183° C.Add five drops of a solution of chromium trioxide (1 in 20) to 5 cc. of a solution of Cocaine Hydrochloride (1 in 50) a yellow precipitate is produced which redissolves on shaking the mixture. On the addition of 1 cc. of hydrochloric acid, a permanent, orange-colored, crystalline precipitate is formed. A solution of about 0.01 Gm. of Cocaine Hydrochloride in 1 cc. of distilled water yields on the addition of 2 cc. of tenth-normal potassium permanganate a violet, crystalline precipitate which appears brownish-violet when collected on a filter, and shows characteristic, crystalline aggregates under the low power of a microscope. Heat about 0.1 Gm. of powdered Cocaine Hydrochloride with 1 cc. of sulphuric acid for five minutes, then cautiously mix with 2 cc. of distilled water the aromatic odor of methyl benzoate is noticeable and on cooling crystals of benzoic acid separate. Silver... 

At the back of this book, you will find resources, web sites, and organizations that can supply you with additional information about cocaine. 

You cannot force a friend or family member to admit that they have a problem with cocaine or force them to stop—they have to do that themselves. However, there are certain things you can do to help someone you care about who is abusing cocaine. The first thing you can do is talk to someone you can trust about your friend s problem—perhaps a counselor, a teacher, a doctor, or a parent. Ask him or her to keep what you are sharing confidential. You don t even need to mention your friend s name. Adults can often provide you with additional resources or information that may be helpful as you decide what to do next. 

A study in 30 patients being evaluated for chest pain found that 2 mg/kg of a 10% intranasal solution of cocaine reduced coronary sinus flow hy about 14% and coronary artery diameter by 6 to 9%. The coronary vascular resistance increased by 22%. The addition of propranolol 400 micrograms/minute by intracoronary infusion, (to a total of 2 mg) reduced coronary sinus flow by a further 15% and increased the coronary vascular resistance by 17%. The probable reason is that the cocaine stimulates the alpha-receptors of the coronary blood vessels causing vasoconstriction. When the beta-receptors are blocked by propranolol, the resultant unopposed alpha-adrenergic stimulation may lead to enhanced coronary vasoconstriction (see also Beta blockers + Inotropes and Vasopressors , p.848). The clinical importance of these frndings is uncertain but the authors of the report suggest that beta blockers should be avoided in patients with myocardial ischaemia or infarction associated with the use of cocaine. ... 

This treatment had no effect on the subsequent acidimetric titration of the cocaine. It was also noted that the addition of about 10 per cent of 95 per cent ethanol to the ether used in the extraction of coca leaves tends to reduce emulsions and thus shortens the time required for analysis without affecting the results. 

Dissolve the extracted residue in 0 1 N sulphuric acid and add a solution of 3 per cent potassium permanganate in 0 5N sulphuric acid until an excess is indicated by the colour. After the solution has been decolorised with oxalic acid add sodium bicarbonate in excess and extract any cocaine with light petroleum immediately after the addition of the bicarbonate. Oxidation can be hastened by keeping the solution in a water-bath at about 60°. 

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