Co-carcinogenic effects

KIM J p, PARK J G, LEE M D, HAN M D, PARK s T, LEE B H, JUNG se(1985) Co-carcinogenic effects of several Korean foods on gastric cancer induced by N-methyl-N -nitro-N-nitrosoguanidine in rats. . Jpn J Surg. 15 427-37. 

Paolini, M., Cantelli-Forti, G., Perocco, P., Peduli, G.F., Abdel-Rahman, S.Z., and Legator, M.S. 1999. Co-carcinogenic effect of beta-carotene. Nature 398 760-761. 

Pence BC, Buddingh E Co-carcinogenic effect of carbon black ingestion with dietary fat on the development of colon tumors in rats. Toxfro/37 177-182, 1987... 

Kimizuka G, Azuma M, Ishibashi M, et al. 1993. Co-carcinogenic effect of chrysotile and amosite asbestos with benzo(a)pyrene in the lung of hamsters. Acta Pathol Jpn 43(4) 149-153. 

Kim JP, Park JG, Lee MD et al. Co-carcinogenic effects of several Korean foods on gastric cancer... 

Lastly, mention should be made of a recent study of the possible co-carcinogenic effects of bile salts in which enhanced uptake by the colon of 7,12-dimethylbenzanthracene was demonstrated in the presence of deoxycholic add [114]. It is very likely that this reflects an increase in mucosal permeability caused by this secondary bile acid. 

One problem with such approaches is that one cannot a priori equate the behavior of a single component or a separate fraction in isolation from its behavior as part of a complex mixture. There are many examples where, following fractionation procedures, the sum of the parts does not equal the whole. There are other examples where the combination of components will multiply or accentuate the effect of one component in isolation. Such examples demonstrate co-mutagenic or co-carcinogenic effects. 

Cruse JP, Lewin MR, Ferulano GP, Clark CG (1978) Co-carcinogenic effects of dietary cholesterol in experimental colon cancer. Nature 276(5690) 822-825... 

In searching for an explanation for how the ingestion of L-tryptophan may be involved in the process of chemical carcinogenesis in experimental studies, several studies have concluded that L-tryptophan acts as a co-carcinogen or promoter.250 252 275 Some of the following effects or actions of L-tryptophan may influence such processes in carcinogenesis. 

Although beechwood creosote, creosote bush resin, and coal tar creosote have some components in common, such as phenols, it is not known whether these mixtures will induce the same effects. Furthermore, coal tar creosote contains a complex mixture of animal and human carcinogenic and co-carcinogenic PAHs that probably accounts for the cancer risk associated with chronic exposure to coal tar creosote while wood creosote does not. 

Dimethylarsinic acid (v) Mammalian cells genotoxic and clastogenic effects S S S S S dS0,4Si viability and growth of human 06118 Rats reduction in brain neuron viability apotopsis cancer promoter—bladder, kidney, liver, thyroid Mice carcinogenic, co-carcinogenic or cancer promoter—skin, bladder induction of aneuploidy ... 

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