Clinical biochemical determinations sensitivity

There is a continuing demand for fast and simple analytical methods for the determination of many clinical, biochemical and environmental analytes. In this respect, immunoassays and immunosensors that rely on antibody-antigen interactions provide a promising means of analysis owing to their specificity and sensitivity. High specificity... 

While biochemical markers of bone metabolism may be sensitive to the effects of glucocorticoids in the short term, the relation between changes in these markers and intermediate measures, such as bone mineral density, and the more important clinical outcomes of fractures, is unknown. In a random stratified sample of 3222 women in the perimenopausal age range (47-56 years), including 119 women with asthma, bone mineral density was measured to determine whether asthma was a risk factor of osteoporosis and to investigate the effect of inhaled glucocorticoids (102). The subjects had predominantly adult-onset asthma, as the age at diagnosis was over 40 years. There were 26 patients who were treated mainly with... 

Xu Q, Zhu JJ, Hu XY (2007) Ordered mesoporous polyanifine film as a new matrix for enzyme immobilization and biosensor construction. Anal Chun Acta 597(1) 151—156 Yakovleva J, Davidsson R, Lobanova A et ak (2002) Enzyme immunoassay using silicon microchip with immobilized antibodies and chemiluminescence detection. Antd Chem 74(13) 2994—3004 Yamada H, Kobayashi M (1996) Nitrile hydiatase and its application to industrial production of acrylamide. Biosci Biotechnol Biochem 60 1391—1400 Yamamoto K, Ohgam T, Torimura M et al. (2000) Highly-sensitive flow injection determination of hydrogen peroxide with a peroxidase-immobilized electrode and its application to clinical chemistry. Anal Chim Acta 40(2) 201—207... 

HPLC. The proposed method is rapid, low cost, simple, and sensitive and is promising to determine all beta-blockers, especially to monitor bisoprolol in clinical and biochemical samples in future [68]. 

The advantages of IC-MS such as sensitivity and selectivity are noticeable in the analysis of drinking water (e.g., for the determination of perchlorate, the analysis of haloacetic acids or of disinfection by-products). Other fields of >pli-cation are clinical and biochemical research (determination of organic acids, amines, or sugars),pharmaceutical industry (peak identification and purity tests), petrochemical industry (determination of indicator substances), food industry, electroplating industry, analysis of hazardous substances, and environmental analysis. " ... 

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