Cisplatin gastric cancer

Koizumi W, Tanabe S, Saigenji K et al. Phase I/II study of S-1 combined with cisplatin in patients with advanced gastric cancer. Br J Cancer 2003 89 2207-2212. 

High tumor tissue levels of ERCCl mRNA in ovarian and gastric cancer patients have been associated with cisplatin resistance (24,25). Similarly, inhibition of ERCCl expression has been significantly associated with reduced HCR of cisplatin-treated cells... 

Cisplatin has major antitumor activity in a broad range of solid tumors, including non-small cell and small cell lung cancer, esophageal and gastric cancer, head and neck cancer, and genitourinary cancers, particularly testicular, ovarian, and bladder cancer. When used in combination regimens with vinblastine and bleomycin or etoposide and bleomycin, cisplatin-based therapy has led to the cure of nonseminomatous testicular cancer. 

SKI 2053R (7), containing an even bulkier amine hgand than (6), was shown to be active in murine leukemia with acquired resistance to cisplatin. Clinical activity in cisplatin-resistant tumors has not yet been reported. On the basis of studies in gastric cancer patients, SKI 2053R has received approval in South Korea. ... 

Nakagawa H, Kobayashi K, Tone T, Fukuda K, Shinn E, Mishima H, Yagyu T, Kobayashi T, Kikkawa N. [Combination of intra-hepatic arterial infusion of low-dose cisplatin and oral administration of high-dose doxyfluridine for patients with liver metastases of gastric cancer.] Gan To Kagaku Ryoho 1996 23(6) 783-5. 

Ahn JH, Kang YK, Kim TW, Bahng H, Chang HM, Kang WC, Kim WK, Lee JS, Park JS. Nephrotoxicity of heptaplatin a randomized comparison with cisplatin in advanced gastric cancer. Cancer Chemother Pharmacol 2002 50(2) 104-10. 

Okuyama T, Maehara Y, Endo K, Baba H, Adachi Y, Kuwano M, Sugimachi K (1994) Expression of glutathiraie S-transferase-pi and sensitivity of human gastric cancer cells to cisplatin. Cancer 74(4) 1230-1236... 

Recently we have also obtained a similar median survival time, that is about 8 mondis, in advanced gastric cancer after the treatment with 5-FU and cisplatin. ... 

V anhoefer U, Harstrick A, Wilke H, Schleucher N, WaUes H, Schroder J, Seeber S. Schedule-dependent antagonism of paclitaxel and cisplatin in human gastric and ovarian carcinoma cell lines in vitro. Eur J Cancer 1995 31 A(l) 92-7. 

Goto, H., Tachi, K., Arisawa, T., Niwa, Y, Hayakawa, T., and Sugiyama, S. (1998) Effects of gamma-glutamylcysteine ethyl ester in cisplatin-induced changes in prostanoid concentrations in rat gastric and colonic mucosa. Cancer Detect. Prev. 22 153-160. 

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